脑心通胶囊联合帕罗西汀治疗脑卒中后抑郁症临床研究

Clinical Study on Naoxintong Capsules Combined with Paroxetine for Post-Stroke Depression

目的:观察脑心通胶囊联合帕罗西汀治疗脑卒中后抑郁症(PSD)的临床疗效。方法:选取85例PSD患者作回顾性研究对象,根据不同治疗方式分成观察组43例和对照组42例。对照组予以帕罗西汀治疗,观察组给予帕罗西汀联合脑心通胶囊治疗。采用汉密尔顿抑郁量表(HAMD)对2组抑郁程度进行评价,并检测2组治疗前后前列腺素E_(2)(PGE_(2))、同型半胱氨酸(Hcy)、白细胞介素-23 (IL-23)、白细胞介素-10 (IL-10)、肿瘤坏死因子-α(TNF-α)水平。结果:治疗前,2组HAMD评分比较,差异无统计学意义(P>0.05);治疗1、4、8周时,观察组HAMD评分均低于对照组,差异有统计学意义(P<0.05)。治疗前,2组Hcy、PGE_(2)水平比较,差异无统计学意义(P>0.05);治疗后,观察组Hcy水平低于对照组,PGE_(2)水平均高于对照组,差异均有统计学意义(P<0.05)。治疗前,2组IL-23、IL-10、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,观察组IL-23、IL-10、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。结论:脑心通胶囊联合帕罗西汀治疗PSD能有效调节血清Hcy、PGE_(2)水平,减轻炎症反应,显著改善患者抑郁状态。

Objective:To observe the clinical effect of Naoxintong capsules combined with paroxetine for post-stroke depression(PSD). Methods: A total of 85 cases of PSD patients were selected as retrospective study objects, and were divided into the observation group and the control group according to different treatment methods,with 43 and 42 cases in each group respectively. The control group was treated with paroxetine, and the observation group was treated with paroxetine combined with Naoxintong capsules. The degrees of depression in the two groups were evaluated by Hamilton Depression Scale(HAMD). Before and after treatment,the levels of estradiol(E_(2)),homocysteine(Hcy),interleukin-23(IL-23),interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α) in serum in the two groups were detected.Results: Before treatment,there was no significant difference being found in the comparison of HAMD scores between the two groups(P>0.05). After one,four and eight weeks of treatment respectively,HAMD scores in the observation group were lower than those in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of Hcy and E_(2)between the two groups(P>0.05). After treatment,Hcy level in the observation group was lower than that in the control group,and E_(2)level was higher,differences being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of IL-23,IL-10 and TNF-αbetween the two groups(P>0.05). After treatment,the levels of IL-23,IL-10 and TNF-α in the observation group were lower than those in the control group, the difference being significant(P<0.05). Conclusion: The therapy of Naoxintong capsules combined with paroxetine for PSD can effectively regulate the levels of Hcy and E_(2)in serum,reduce inflammatory responses,and significantly improve the depressive state of patients.