百令胶囊联合普米克令舒吸入治疗老年咳嗽变异性哮喘临床研究

Clinical Study on Bailing Capsules Combined with Inhalation of Pulmicort Respules for Senile Cough Variant Asthma

目的:观察百令胶囊联合普米克令舒吸入治疗老年咳嗽变异性哮喘的临床疗效。方法:选取108例老年咳嗽变异性哮喘患者,按随机数字表法分为对照组和观察组各54例。对照组给予普米克令舒雾化吸入治疗,观察组在对照组的基础上给予百令胶囊治疗。2组均以4周为1个疗程,治疗3个疗程后比较2组临床疗效、肺功能指标及炎症因子水平。结果:治疗后,观察组临床总有效率为90.74%,高于对照组的79.53%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组最大呼气流量(PEF)、第1秒呼气容积(FEV_(1))、第1秒用力呼气容积占用力肺活量比值(FEV_(1)/FVC)水平比较,差异均无统计学意义(P>0.05);治疗后,2组PEF、FEV_(1)、FEV_(1)/FVC水平均较治疗前明显升高(P<0.05),且观察组各项指标均高于对照组(P<0.05)。治疗前,2组白细胞介素-4与干扰素-γ的比值(IL-4/IFN-γ)、白细胞介素-17 (IL-17)水平比较,差异均无统计学意义(P>0.05);治疗后,2组IL-4/IFN-γ、IL-17水平均较治疗前明显降低(P<0.05),且观察组2项指标均低于对照组(P<0.05)。治疗前,2组血清辅助性T细胞(Th17)、调节性T细胞(Treg)及Th17/Treg水平比较,差异均无统计学意义(P>0.05);治疗后,2组Th17、Th17/Treg水平较治疗前明显降低(P<0.05),Treg水平较治疗前明显升高(P<0.05);且观察组上述指标改善较对照组更显著(P<0.05)。结论:百令胶囊联合普米克令舒吸入治疗老年咳嗽变异性哮喘疗效显著,可有效减轻机体炎症反应,改善患者肺功能。

Objective:To observe the clinical effect of Bailing capsules combined with inhalation of pulmicort respules on senile cough variant asthma. Methods:A total of 108 elderly patients with cough variant asthma were selected and divided into the control group and the observation group according to the random number table method,with 54 cases in each group.The control group was treated with aerosol inhalation of pulmicort respules, and the observation group was additionally treated with Bailing capsules based on the treatment of the control group. Both groups were treated for three courses,four weeks being a course. After treatment,the clinical effects,lung function indexes and levels of inflammatory factors in the two groups were observed and compared. Results: After treatment, the total clinical effective rate was 90.74% in the observation group, higher than that of 79.53% in the control group, the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of levels of peak expiratory flows(PEF),forced expiratory volume in one second(FEV_(1)) and the ratio of forced expiratory volume in one second to forced vital capacity(FEV_(1)/FVC) between the two groups(P>0.05);after treatment,the above levels in both groups were significantly increased when compared with those before treatment(P<0.05),and the above indexes in the observation group were higher than those in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparison of ratio of interleukin-4 to interferon-γ(IL-4/IFN-γ) and level of interleukin-17(IL-17) between the two groups(P>0.05);after treatment, the above two indexes in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above two indexes in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of serum T helper 17(Th17)cells,regulatory T(Treg) cells and Th17/Treg between the two groups(P>0.05);after treatment,the levels of Th17 and Th17/Treg in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the levels of Treg were significantly increased(P<0.05),and the improvement of the above indexes in the observation group was more significant than that in the control group(P<0.05). Conclusion:The therapy of Bailing capsules combined with inhalation of pulmicort respules for senile cough variant asthma has a significant curative effect, which can effectively reduce the inflammatory responses of the bodyand improve the lung function of patients.