苓皮除湿宣痹方加减联合蜡疗治疗膝关节滑膜炎临床研究

Clinical Study on Modified Lingpi Chushi Xuanbi Prescription Combined with Wax Treatment for Knee Joint Synovitis

目的:观察苓皮除湿宣痹方加减联合蜡疗治疗膝关节滑膜炎的临床疗效。方法:选取100例膝关节滑膜炎患者,随机分为对照组和观察组,每组50例。对照组给予双氯芬酸二乙胺乳胶剂治疗,观察组给予苓皮除湿宣痹方加减联合蜡疗治疗,2组均连续治疗8周。比较2组临床疗效及治疗前后症状评分、视觉模拟评分法(VAS)评分、西安大略和麦马斯特大学骨关节指数(WOMAC)、C-反应蛋白(CRP)、红细胞沉降率(ESR)。结果:观察组总有效率86.00%,高于对照组72.00%(P<0.05)。治疗后,2组关节疼痛、关节肿胀、活动障碍、下肢痿软无力评分均较治疗前降低(P<0.05),观察组上述4项症状评分均低于对照组(P<0.05)。治疗后,2组VAS、WOMAC评分均较治疗前降低(P<0.05),观察组VAS、WOMAC评分均低于对照组(P<0.05)。治疗后,2组CRP、ESR水平均较治疗前降低(P<0.05),观察组CRP、ESR水平均低于对照组(P<0.05)。结论:苓皮除湿宣痹方加减联合蜡疗治疗膝关节滑膜炎疗效较好,能够减轻患者的膝关节疼痛症状,改善膝关节功能,控制炎症反应。

Objective: To observe the clinical effect of modified Lingpi Chushi Xuanbi prescription combined with wax treatment for knee joint synovitis. Methods:A total of 100 cases of patients with knee joint synovitis were randomly divided into the control group and the observation group,with 50 cases in each group. The control group was treated with diclofenac diethylamine emulsion, and the observation group was treated with modified Lingpi Chushi Xuanbi prescription combined with wax treatment. Both groups were treated for eight weeks. The clinical effect in the two groups was compared. Before and after treatment, the scores of symptom, visual analogue scale and Western Ontario and Mcmaster Universities Osteoarthritis Index(WOMAC) as well as the levels of C-reactive protein(CRP) and erythrocyte sedimentation rate(ESR).Results:The total effective rate was 86.00% in the observation group,higher than that of 72.00% in the control group(P<0.05). After treatment, the scores of joint pain, joint swelling, movement disorder and lower limb weakness in the two groups were lower than those before treatment(P<0.05),and the scores of the above four symptoms in the observation group were lower than those in the control group(P<0.05). After treatment, the VAS and WOMAC scores of the two groups were lower than those before treatment(P<0.05), and the VAS and WOMAC scores in the observation group were lower than those of the control group(P<0.05). After treatment,the levels of CRP and ESR in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of CRP and ESR in the observation group were lower than those in the control group(P<0.05). Conclusion:Modified Lingpi Chushi Xuanbi prescription combined with wax treatment has a good curative effect in treating knee joint synovitis,which can relieve symptoms of pain in the knee joint,improve knee joint function and control inflammatory responses.