针灸治疗癌因性疲乏随机对照试验结局指标的现状分析

Analysis of the Current Status Quo of Outcomes of Randomized Controlled Trials of Acupuncture and Moxibustion Treatment for Cancer-Related Fatigue

目的 评价针灸治疗癌因性疲乏随机对照试验选用结局指标的情况,为针灸治疗癌因性疲乏核心指标集研究提供参考。方法 计算机检索PubMed、EMbase、The Cochrane Library、Web of Science、中国生物医学、中国知网、万方和维普中文期刊全文数据库,搜集该随机对照试验,截止时间为2020年10月。由2位评价员独立筛选文献、采集资料,再采用定性分析的方法归纳结局指标。结果 共检索76篇文献,经分析发现有如下问题:疲乏量表评价标准不统一;试验中缺乏对样本量的估算和盲法的考虑,导致偏倚风险较高;客观性指标所占比重较轻。结论 针灸治疗癌因性疲乏的结局指标应构建以中医理论为核心,以客观指标为主,主观指标为辅的结局指标集。

Objective To evaluate the current state with regard to the selection of outcomes required for the randomizedcontrolled trials(RCTs) on the acupuncture and moxibustion in the treatment of cancer-related fatigue(CRF), whichcould provide reference for the research on the acupuncture and moxibustion treatment for CRF. Methods We usedcomputer to search Pub Med, EMbase, Cochrane Library, Web of Science, China Biology Medicine disc(CBM), CNKI,Wanfang Data(WF) and VIP Chinese Journal Database(VIP) and collected the information of RCTs about theacupuncture and moxibustion in the treatment of CRF, with the deadline of retrieval set to October 2020. After tworeviewers separately screened the literature and collected data. Qualitative analysis was carried out to describe theoutcome indicators of the included study.Results In total, 76 pieces of literature were retrieved, and some problemswere discovered as follows. For example, the fatigue scale evaluation standards were not unified, while the lack of samplesize estimation and blinding considerations in the experiment increased the risk of deviation and led to a smallerproportion of objective indicators.Conclusion It is necessary to construct a set of outcome indicators using the theory of traditional Chinese medicine, with those objective indicators as the mainstay and subjective indicators as asupplementary.