肿瘤中长链非编码RNA GIHCG的表达及作用研究进展

Research Progress on Expression and Roles of Long Non-coding RNA GIHCG in Tumors

长链非编码RNA(long non-coding RNA,lncRNA)是一类长度大于200个核苷酸且基本不能编码蛋白质的RNA分子,在诸多肿瘤中表达异常的lncRNA能够参与调控肿瘤的发生与发展。长链非编码RNA GIHCG(gradual increased during hepatocarcinogenesis)是近年在肝细胞癌研究中新发现的一种lncRNA,其异常高表达与多种恶性肿瘤患者预后密切相关。GIHCG可通过内源竞争性吸附miRNA、调节细胞周期以及激活多种信号通路来调控肿瘤的恶性生物学行为,对GIHCG作用的研究有助于相关肿瘤的诊断、治疗及评估预后。全文就肿瘤中长链非编码RNA GIHCG的表达及作用的研究进展进行综述。

Long non-coding RNAs(lncRNAs)are RNA molecules with a length of more than 200 nucleotides,which are basically unable to encode protein.Researches have shown that abnormally expressed lncRNAs may participate in the development and progression of various malignant tumors.lncRNA GIHCG(gradual increased during hepatocarcinogenesis)is a newly discovered lncRNA,its abnormally high expression is closely associated with the prognosis of many kinds of tumors.GIHCG can regulate the malignant biological behaviors of tumors through endogenous competitive adsorption of miRNA,regulating cell cycle and activating multiple signal pathways.This article reviews the recent progress on the expression and roles of lncRNA GIHCG in malignant tumors,which may be conducive to diagnosis,treatment and prognostic assessment of relevant tumors.