超声监控下聚桂醇消融治疗甲状腺良性结节的效果及影响患者疗效的相关因素分析

Effect of lauromacrogol ablation under ultrasound monitoring on benign thyroid nodules and analysis of related factors affecting the curative effect of patients

目的 探究超声监控下聚桂醇消融治疗甲状腺良性结节的效果及影响患者疗效的相关因素分析。方法 选取本院2019年4月至2021年4月接诊的130例甲状腺良性结节患者,随机将其分为手术组(传统甲状腺结节切除术)和消融组(超声监控下聚桂醇消融),每组65例。比较两组不同性质结节的体积缩小率及治疗前、后的甲状腺功能指标,并采用单因素及多因素Logistic回归分析进行甲状腺结节患者疗效的影响因素分析。结果 两组患者不同性质结节的体积均缩小,缩小率由高到低依次为囊性结节、囊实混合性结节、实性结节,但消融组不同性质结节体积缩小率均高于手术组(P<0.05)。两组患者治疗前、后的TSH、FT3、FT4水平均在正常范围内,且组间比较,差异无统计学意义(P>0.05)。多因素Logistic回归分析发现,性别、结节基线体积和治疗方式是影响患者疗效的独立危险因素(P<0.05)。结论 超声监控下聚桂醇消融治疗甲状腺良性结节能够提高结节体积缩小率,疗效显著,且无安全性问题。在临床病理参数中,性别、结节基线体积和治疗方式是影响甲状腺结节患者疗效的相关因素。

Objective To explore the effect of lauromacrogol ablation under ultrasound monitoring on benign thyroid nodules and analysis of related factors affecting the curative effect of patients.Methods One hundred and thirty patients with benign thyroid nodules treated in our hospital from April 2019 to April 2020 were selected and randomly divided into operation group(traditional thyroidectomy) and ablation group(lauromacrogol ablation under ultrasound monitoring),with65 cases in each group.The volume reduction rate of nodules with different properties and thyroid function indexes before and after treatment were compared between the two groups,and the factors influencing the efficacy of thyroid nodules were analyzed by univariate and multivariate Logistic regression analysis.Results The volume of nodules with different properties in the two groups decreased,and the reduction rate from high to low was cystic nodules,cystic solid mixed nodules and solid nodules,but the volume reduction rate of nodules with different properties in the ablation group were higher than those in the operation group(P<0.05).TSH,FT3and FT4levels in the two groups were within the normal range before and after treatment,and there were no significant differences between the two groups(P>0.05).Multivariate Logistic regression analysis showed that gender,nodules baseline volume and treatment mode were independent risk factors affecting the curative effect of patients(P<0.05).Conclusion Lauromacrogol ablation under ultrasound monitoring in the treatment of benign thyroid nodules can improve the volume reduction rate of nodules,with significant efficacy and no safety issues.Among the clinicopathological parameters,gender,nodules baseline volume and treatment mode are the relevant factors affecting the curative effect of thyroid nodules.