不同产地、不同部位乌药中31种无机元素测定及初步风险评估

Determination and primary risk evaluation of 31 inorganic elements in Lindera aggregata(Sims)Kosterm.from different habitat and medication part

目的:分析研究不同产地、不同部位乌药中31种无机元素的含量,对其中5种重金属及有害元素进行风险评估和最大限量理论值计算,为质量保证提供依据。方法:采用电感耦合等离子体质谱(ICP-MS)法测定乌药中31种无机元素,建立无机元素特征图谱;采用危害指数法(HI法)对5种重金属及有害元素的风险进行评估,并计算其最大限量理论值。结果:31种无机元素线性关系良好,相关系数r≥0.9941、回收率在88.7%~104.1%,RSD均小于3.6%。风险评估结果表明不同部位乌药中5种重金属及有害元素的风险可控,HI均小于1。经过计算得到乌药不同样品中Hg、Cu、As的实际测定值远小于最大限量值,除浙江天台产乌药叶外,其余样品Cd元素均超限;样品中Pb元素超限,其中广东韶关产乌药中块根和直根中Pb超限。结论:该方法可以用于不同部位乌药中无机元素测定,适用于乌药中重金属及有害元素的风险评估,为乌药的质量控制及安全性评价提供依据。

Objective:To analyze the contents of 31 inorganic elements in Lindera aggregate(Sims)Kosterm.(L.aggregata),and to perform the risk evaluation and the theoretical limits for 5 heavy metals and harmful elements in order to provide reference for quality assurance.Methods:The contents of 31 inorganic elements were determined by inductively coupled plasma mass spectrometry(ICP-MS),the risk of heavy metals and harmfulelements were assessed deterministically by the methods of hazardous index(HI),and the theoretical limits for heavy metals and harmful elements were calculated.Results:The determination results of 31 kinds of inorganic elements all had a good linear relationship with r≥0.9941.The recoveries were 88.7%-104.1%with RSDs≤3.6%.The risk assessment results showed that the risk of 5 heavy metals and harmful elements in different parts of L.aggregata was controllable,and HIs were all below 1.After calculation,the actual measured values of Hg,Cu and As in different samples were far less than the theoretical limits.Except for the leaves of L.aggregata from Tiantai,contents of other samples exceeded the limit of Cd.The contents of Pb in the samples exceeded the limit,and the contents of Pb in the root tubers and taproots from Shaoguan,Guangdong Province exceeded the limit.Conclusion:This method can be used for the determination of inorganic elements in different parts of L.aggregata,and is suitable for the risk assessment of heavy metals and harmful elements in L.aggregata,which provides a basis for the quality control and safety evaluation of L.aggregata.