血管内皮细胞生长因子抑制剂在新生血管性青光眼治疗中的价值研究

Value of Vascular Endothelial Cell Growth Factor Inhibitors in Treatment of Neovascular Glaucoma

目的:探讨血管内皮细胞生长因子抑制剂在新生血管性青光眼(NVG)患者中的疗效。方法:将2019年2月-2020年11月南华大学附属长沙中心医院收治的84例NVG患者分两组,各42例。参照组患者实施视网膜激光光凝及复合式小梁切除手术治疗,研究组在参照组基础上采用血管内皮细胞生长因子抑制剂治疗。观察两组患者临床疗效,不良反应发生率,生活质量评分,临床指标[眼压、最佳矫正视力(BCVA)、血管内皮生长因子(VEGF)、基质细胞衍生因子-1(SDF-1)、胰岛素样生长因子-1(IGF-1)]情况。结果:研究组治疗后总有效率高于参照组,不良反应发生率低于参照组,两组比较差异有统计学意义(P<0.05)。研究组治疗后生活质量评分优于参照组(P<0.05)。两组患者治疗后,眼压、BCVA、VEGF、SDF-1和IGF-1水平均低于治疗前(P<0.05),且观察组各指标改善水平均低于参照组,差异有统计学意义(P<0.05)。结论:血管内皮细胞生长因子抑制剂联合视网膜激光光凝及复合式小梁切除手术治疗NVG具有显著效果,值得临床推广。

Objective: To investigate the efficacy of vascular endothelial cell growth factor inhibitors in patients with neovascular glaucoma(NVG). Methods: From February 2019 to November 2020, 84 NVG patients admitted to Changsha Central Hospital Affiliated to University of South China were divided into two groups, with 42 cases in each group. The patients in the reference group were treated with retinal laser photocoagulation and compound trabeculectomy, and the patients in the study group were treated with vascular endothelial cell growth factor inhibitors on the basis of the reference group. The clinical efficacy, incidence of adverse reactions, quality of life scores, and clinical indicators [intraocular pressure, best corrected visual acuity(BCVA),vascular endothelial growth factor(VEGF), stromal cell-derived factor-1(SDF-1), and insulin-like growth factor-1(IGF-1)] of patients in two groups were observed. Results: After treatment, the total effective rate of the study group was higher than that of the reference group, and the incidence of adverse reactions was lower than that of the reference group, and the difference between the two groups was statistically significant(P<0.05). The quality of life scores of the study group after treatment were better than those of the reference group(P<0.05). After treatment, the levels of intraocular pressure, BCVA, VEGF, SDF-1 and IGF-1 in the two groups were lower than those before treatment(P<0.05), and the improvement level of each index in the observation group was lower than that in the reference group, and the difference was statistically significant(P<0.05). Conclusion: Vascular endothelial cell growth factor inhibitors combined with retinal laser photocoagulation and compound trabeculectomy in the treatment of NVG has a significant effect, which is worthy of clinical promotion.