miR-18a、miR-92a水平与宫颈癌患者淋巴结转移的相关性

Correlation between serum miR-18a,miR-92a levels and lymph node metastasis in patients with cervical cancer

目的分析血清微小核糖核酸(miR)-18a、miR-92a水平与宫颈癌患者淋巴结转移的关系。方法选取2018年1月至2020年1月西安市人民医院收治的78例宫颈癌患者作为研究对象。评估所有患者入院时淋巴结转移发生情况,并分为转移组与未转移组。设计基线资料调查表,统计两组基线资料,重点分析入院时血清miR-18a、miR-92a水平与宫颈癌患者淋巴结转移的关系。结果78例宫颈癌患者发生淋巴结转移16例,占比20.51%;转移组与未转移组的血清miR-18a、miR-92a水平比较,差异具有统计学意义(P<0.05);两组其他基线资料比较,差异无统计学意义(P>0.05);Logistic回归分析结果显示,入院时血清miR-18a、miR-92a异常表达可能与宫颈癌患者淋巴结转移有关,两者过表达可能是宫颈癌患者淋巴结转移的风险因子(OR>1,P<0.05);绘制受试者工作特征曲线,结果显示,宫颈癌患者入院时血清miR-18a、miR-92a水平评估淋巴结转移风险的曲线下面积均>0.80,评估价值均理想,且以联合评估的价值最高。结论入院时血清miR-18a、miR-92a过表达可能与宫颈癌患者淋巴结转移有关。

Objective To analyze the relationship between serum microRNA(miR)-18 a,miR-92 a levels and lymph node metastasis in patients with cervical cancer.Methods 78 patients with cervical cancer treated in Xi′an People′s Hospital from January 2018 to January 2020 were selected,the occurrence of lymph node metastasis of all patients was evaluated at admission and divided them into the metastasis group and the non-metastasis group.The baseline data questionnaire was designed to count the baseline data of the two groups,and analyze the relationship between serum miR-18 a,miR-92 a levels and lymph node metastasis of cervical cancer patients at admission.Results Lymph node metastasis occurred in 16 cases(20.51%)of 78 cervical cancer patients.There were statistically significant differences in serum miR-18 a and miR-92 a levels between the metastatic group and the non-metastatic group(P<0.05).There was no significant difference in other baseline data between the two groups(P>0.05).Logistic regression analysis showed that abnormal expression of miR-18 a and miR-92 a in serum at admission may be associated with lymph node metastasis in patients with cervical cancer,and overexpression of miR-18 a and miR-92 a may be risk factors for lymph node metastasis in patients with cervical cancer(OR>1,P<0.05).The receiver operating characteristic curve showed that the area under the curve of serum miR-18 a and miR-92 a levels for evaluating the risk of lymph node metastasis in patients with cervical cancer at admission was>0.80,and the evaluation value was ideal,and the combined evaluation value was the highest.Conclusions The overexpression of serum miR-18 a and miR-92 a at admission may be related to lymph node metastasis in patients with cervical cancer.