摘要
The worldwide paucity of transplantable organs for patients is a devastating problem.While different approaches have been conceived to address this donor organ shortage,one strategy that has garnered significant attention recently is the prospect of producing human organs in animals through a technique called interspecies blastocyst complementation based on the generation of interspecies chimeras.Interspecies blastocyst complementation works by injecting pluripotent stem(PS)cells from one species into organogenesis-disabled blastocysts of another species(Kobayashi et al.,2010).As the chimeric embryo develops,donor cells can fill the vacated developmental organ niche and enrich in a target organ of interest.In principle,interspecies blastocyst complementation may one day allow the generation of human organs inside animals.However,some ethical issues concerning research and potential human clinical use with chimeras persist(Hyun,2019).
