脐灸对急性淋巴细胞白血病患者接受化学药物治疗期间肠道菌群失调的改善效果

Effect of umbilical moxibustion on improving intestinal flora dysregulation in patients with acute lymphoblastic leukemia during chemotherapy

目的探究脐灸对急性淋巴细胞白血病(ALL)患者接受化学药物治疗(简称“化疗”)期间肠道菌群失调的改善效果。方法选取2020年2~10月佛山市南海区人民医院收治的122例接受化疗的ALL患者为研究对象,按照随机数字表法分为对照组(61例)和观察组(61例)。对照组患者接受常规治疗,观察组患者在常规治疗的基础上接受脐灸治疗。观察并比较2组患者的胃肠道功能和肠道菌群水平。结果治疗前,2组间内毒素、胃动素、促胃液素和D-乳酸水平的差异均无统计学意义(P均>0.05)。治疗4周后,2组的胃动素和促胃液素水平均较同组干预前显著升高(P均<0.01),内毒素和D-乳酸水平均较同组干预前显著下降(P均<0.01);观察组的胃动素和促胃液素水平均高于对照,内毒素和D-乳酸水平均低于对照组,差异均有统计学意义(P均<0.05)。治疗前,2组间乳杆菌、双歧杆菌、肠球菌和大肠埃希菌水平的差异均无统计学意义(P均>0.05)。治疗4周后,2组的乳杆菌和双歧杆菌水平均显著高于同组治疗前(P均<0.01),肠球菌和大肠埃希菌水平均显著低于同组治疗前(P均<0.01);观察组的乳杆菌和双歧杆菌水平均高于对照组,肠球菌和大肠埃希菌水平均低于对照组,差异均有统计学意义(P均<0.05)。结论脐灸治疗有助于改善ALL患者在接受化疗期间的胃肠道功能,调节其肠道菌群失衡。

Objective To explore the effect of umbilical moxibustion on the improvement of intestinal flora dysregulation in patients with acute lymphoblastic leukemia( ALL) during chemotherapy. Methods A total of 122 patients with ALL who received chemotherapy at Foshan Nanhai District People’s Hospital from February to October 2020 were recruited. They were divided into a control group( 61 cases) and an observation group( 61 cases) by using a random number table.The control group received routine treatment,and the observation group received umbilical moxibustion on the basis of routine treatment. The gastrointestinal function and intestinal flora level of the two groups were observed and compared. Results Before the treatment,there were no statistically significant differences in the levels of endotoxin,motilin,gastrin,and D-lactic acid between the two groups( all P > 0. 05). After 4 weeks of treatment,the levels of motilin and gastrin of the two groups were significantly higher than those before the intervention( all P < 0. 01),and the levels of endotoxin and D-lactic acid were significantly lower than those before the intervention( all P < 0. 01). The levels of motilin and gastrin of the observation group were higher than those of the control group,and the levels of endotoxin and D-lactic acid were lower than those of the control group. The differences were statistically significant( all P < 0. 05). Before the treatment,there were no statistically significant differences in the levels of Lactobacillus,Bifidobacterium,Enterococcus and Escherichia coli between the two groups( all P > 0. 05). After 4 weeks of treatment,the levels of Lactobacillus and Bifidobacterium of the two groups were significantly higher than those before the treatment( all P <0. 01),and the levels of Enterococcus and Escherichia coli were significantly lower than those before the treatment( all P < 0. 01). The levels of Lactobacillus and Bifidobacterium of the observation group were higher than those of the control group,and the levels of Enterococcus and Escherichia coli were lower than those of the control group. The differences were statistically significant( all P < 0. 05).Conclusion The umbilical moxibustion is helpful to improve the gastrointestinal function of patients with ALL during chemotherapy and regulate the intestinal flora dysregulation.