非小细胞肺癌中P-MNK1、ZNF217的表达及与预后关系探析

The Expression Level of P-MNK1 and Zinc Finger Protein 217 in Non-small Cell Lung Cancer and Its Relationship with Prognosis

目的探析非小细胞肺癌(NSCLC)丝裂原活化蛋白激酶相互作用激酶1(P-MNK1)、锌指蛋白217(ZNF217)表达水平及其与预后关系。方法选取我院2014年3月至2016年1月收治的120例NSCLC患者作为观察对象,采用定量Q-PCR检测NSCLC组织及其配对癌旁组织的P-MNK1和ZNF217表达水平,统计患者预后生存时间、5年生存率等相关临床数据资料,然后采用多因素Cox比例风险模型分析P-MNK1、ZNF217表达与患者预后的关系。结果NSCLC组织P-MNK1和ZNF217表达水平显著高于癌旁组织差异有统计意义(P<0.05);P-MNK1高表达患者(n=55)1、2、3、5年生存率及中位生存时间(MST)均显著低于P-MNK1低表达患者(n=65),差异有统计意义(P<0.05);ZNF217高表达患者(n=58)1、2、3、5年生存率及MST均显著低于ZNF217低表达患者(n=62),差异有统计意义(P<0.05)。多因素Cox分析显示,P-MNK1及ZNF217高表达、T分期、N分期和癌细胞多器官转移是NSCLC患者预后的独立影响因子。结论P-MNK1、ZNF217在NSCLC组织中表达水平较高,是NSCLC患者预后不良的独立影响因子,可作为NSCLC患者预后评估的参考指标。

Objective To analyze the expression of non-small cell lung cancer(NSCLC)mitogen activated protein kinase interacting kinase 1(P-MNK1)and zinc finger protein 217(ZNF217)level and its relationship with prognosis.Methods A total of 120 NSCLC patients admitted to our hospital from March 2014 to January 2016 were selected as the observation objects.Quantitative Q-PCR was used to detect the expression levels of P-MNK1 and ZNF217 in NSCLC tissue and its paired adjacent tissues,and the prognostic survival time of the patients was calculated.The annual survival rate and other relevant clinical data,and then the multivariate Cox proportional hazard model was used to analyze the relationship between the expression of P-MNK1 and ZNF217 and the prognosis of patients.Results The expression levels of P-MNK1 and ZNF217 in NSCLC tissue were significantly higher than those in adjacent tissues(P<0.05).The expression levels of p-mnk1 and ZNF217 in NSCLC were significantly higher than those in adjacent tissues(P<0.05).The 1,2,3 and 5-year survival rate and MST of patients with high expression of p-mnk1(n=55)were significantly lower than those with low expression of p-mnk1(n=65).The difference was statistically significant(P<0.05).The 1,2,3 and 5-year survival rate and MST of patients with high expression of ZNF217(n=58)were significantly lower than those with low expression of ZNF217(n=62)(P<0.05).Multivariate Cox analysis showed that the high expression of P-MNK1 and ZNF217,T stage,N stage,and multi-organ metastasis of cancer cells were independent factors affecting the prognosis of NSCLC patients.Conclusion P-MNK1 and ZNF217 are expressed at high levels in NSCLC tissues,which are independent factors affecting the prognosis of NSCLC patients,and can be used as reference indicators for prognostic evaluation of NSCLC patients.