血清NSE、1,25-(OH)_(2)D_(3)水平与尘肺病发病风险及其肺部炎症的相关性研究

Correlation between the levels of serum NSE and 1,25-(OH)_(2)D_(3) and the risk of pneumoconiosis and pulmonary inflammation

目的分析血清神经元特异性烯醇化酶(NSE)、1,25-二羟维生素D_(3)[1,25-(OH)_(2)D_(3)]水平与尘肺病发病风险及其肺部炎症的相关性。方法选择该院2018年1月至2021年6月收治的129例尘肺病患者作为观察组,100例同期体检健康者作为对照组;采用化学发光法检测受试者血清中NSE及1,25-(OH)_(2)D_(3)水平;采用酶联免疫吸附试验检测受试者血清中C反应蛋白(CRP)、白细胞介素(IL)-8及肿瘤坏死因子-α(TNF-α)水平;采用Spearman相关性检验分析NSE、1,25-(OH)_(2)D_(3)水平与尘肺病发病的相关性,采用线性回归模型分析NSE、1,25-(OH)_(2)D_(3)与肺部炎症因子的关系。结果观察组血清中NSE水平明显高于对照组(P<0.05),1,25-(OH)_(2)D_(3)水平明显低于对照组(P<0.05);观察组血清中CRP、IL-8、TNF-α水平明显高于对照组(P<0.05);NSE与尘肺病发病呈正相关(r=0.619,P<0.05),1,25-(OH)_(2)D_(3)与尘肺病发病呈负相关(r=-0.632,P<0.05);NSE患者与肺部炎症因子水平呈正相关(r=0.989~0.993,P<0.05);1,25-(OH)_(2)D_(3)与肺部炎症因子呈负相关(r=-0.992~-0.989,P<0.05)。结论血清NSE、1,25-(OH)_(2)D_(3)水平与尘肺病发病风险及肺部炎症相关。

Objective To analyze the correlation between the levels of serum neuron specific enolase(NSE),1,25-dihydroxyvitamin D_(3)[1,25-(OH)_(2)D_(3)]and the risk of pneumoconiosis and pulmonary inflammation.Methods Totally 129 patients with pneumoconiosis treated in the hospital from January 2018 to June 2021 were selected as the observation group and 100 healthy people as the control group.The levels of NSE and 1,25-(OH)_(2)D_(3) in serum were detected by chemiluminescence method.The levels of serum C-reactive protein(CRP),interleukin(IL)-8 and tumor necrosis factor-α(TNF-α)were detected.Spearman correlation test was used to analyze the correlation between the expression of NSE and 1,25-(OH)_(2)D_(3) and the pathogenesis of pneumoconiosis.Linear regression model was used to analyze the relationship between NSE,1,25-(OH)_(2)D_(3) and pulmonary inflammatory factors.Results The level of NSE in the observation group was significantly higher than that in the control group(P<0.05),and the level of 1,25-(OH)_(2)D_(3) was significantly lower than that in the control group(P<0.05).Serum CRP,IL-8 and TNF-αin the observation group were significantly higher than those in the control group(P<0.05).NSE was positively correlated with the pathogenesis of pneumoconiosis(r=0.619,P<0.05),and the expression of 1,25-(OH)_(2)D_(3) was negatively correlated with the pathogenesis of pneumoconiosis(r=-0.632,P<0.05).There was a significant positive correlation between NSE patients and pulmonary inflammatory factors(r=0.989-0.993,P<0.05),and there was a significant negative correlation between 1,25-(OH)_(2)D_(3) and pulmonary inflammatory factors(r=-0.992--0.989,P<0.05).Conclusion The levels of serum NSE and 1,25-(OH)_(2)D_(3) are significantly correlated with the risk of pneumoconiosis and pulmonary inflammation.