摘要
近年来国内外对菊苣酸的研究热度逐年升高,主要研究领域集中在其生物活性与药理作用的探索。本研究团队在菊苣酸的抗病毒研究中,首次发现了其有强效的抗呼吸道合胞病毒活性作用,申请了发明专利并获得了国家科技重大新药创制专项的支持。文章通过统计分析菊苣酸相关文献,全面汇总了菊苣酸的国内外研究进展,讨论了菊苣酸研究的潜在领域与发展方向,以期为菊苣酸的后续开发与研究提供参考。
In recent years, research on chicoric acid has been on the rise worldwide. The main areas of research have been in its biological activity and pharmacological effect. During the antiviral research of chicoric acid, our team discovered for the first time its potent anti-respiratory syncytial virus(RSV) activity, for which a patent for invention has been applied, and which has gained support by the National Science and Technology Project of Major New Drug Development. This article summarizes the research progress of chicoric acid in and outside of China through statistical analysis of relevant literatures, and discusses the potential research fields and development direction in the future, with a view to providing reference for follow-up development and research.
作者
吴超
丛晓娟
高源
李健
李梓欣
田新
吕世洁
李峰
冯帅
WU Chao;CONG Xiao-juan;GAO Yuan;LI Jian;LI Zi-xin;TIAN Xin;LYU Shi-jie;LI Feng;FENG Shuai(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Drug and Food Vocational College,Weihai 264210,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Provincial Collaborative Innovation Center for Traditional Chinese Medicine Quality Control and Construction of Whole Industrial Chain,Jinan 250355,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2021年第12期7234-7238,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重大新药创制专项(No.2017ZX09301058)
山东省医药卫生科技发展计划项目(No.202013030996)。
关键词
菊苣酸
理化性质
生物活性
药理作用
制备工艺
检测方法
研究进展
Chicoric acid
Physicochemical property
Biological activity
Pharmacological effect
Preparation technology
Detection method
Research progress
