还原敏感接枝型两亲性聚氨酯的合成及其胶束性能研究

Synthesis and Micellar Properties of Reduction-sensitive Grafted Amphiphilic Polyurethane

为提高聚氨酯药物载体的稳定性并实现对药物的控制释放,合成了具有还原敏感性的接枝型两亲性聚氨酯(PUSS-g-m PEG)。采用核磁共振氢谱(;H-NMR)和凝胶渗透色谱(GPC)对所得聚氨酯结构进行了表征。结果表明,PUSS-g-m PEG在水中可自组装形成纳米胶束,其在正常生理条件下具有良好的稳定性;PUSS-g-m PEG胶束对阿霉素(DOX)的载药量为1.9%,具有良好的还原敏感释药性能,可实现对DOX的控制释放。

Grafted amphiphilic polyurethane with reduction sensitivity (PUSS-g-m PEG) was synthesized in order to improve the stability of polyurethane drug carriers and realize controlled release of drugs.The structure of the polyurethane was characterized by;H-NMR and GPC.The results showed that PUSS-g-m PEG could self-assemble to form nanomicelles in aqueous solution,which had good stability under normal physiological conditions.The drug load of PUSS-g-m PEG micelles to DOX was 1.9%,which had good reduction-sensitive drug release performance and could achieve controlled release of DOX.