法舒地尔注射液联合颈椎牵引治疗椎动脉型颈椎病的效果

Effect of Fasudil Injection Combined with Cervical Traction on Cervical Spondylosis of Vertebral Artery Type

目的:探讨法舒地尔注射液联合颈椎牵引治疗椎动脉型颈椎病的效果。方法:选取2018年1月-2021年1月环县木钵镇卫生院收治的124例椎动脉型颈椎病患者,随机分为两组。对照组(n=62)进行法舒地尔注射液治疗,研究组(n=62)在对照组基础上进行颈椎牵引治疗。比较两组血流速度、血液流变学指标、生活质量、治疗效果及炎性因子。结果:治疗后,两组右侧椎动脉(RVA)、基底动脉(BA)、左侧椎动脉(LVA)血流速度均明显加快,且研究组快于对照组(P<0.05);两组纤维蛋白原、全血黏度高切、血浆黏度、全血黏度低切水平均明显降低,且研究组低于对照组(P<0.05);两组生活质量评分均明显升高,且研究组评分高于对照组(P<0.05);对照组与研究组的治疗总有效率分别为85.5%、98.4%,研究组高于对照组,差异有统计学意义(P<0.05);两组白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平均降低,且研究组低于对照组(P<0.05)。结论:对椎动脉型颈椎病患者进行法舒地尔注射液联合颈椎牵引治疗,效果理想,可提升患者血流速度,降低血液流变学与炎性因子水平,改善患者生活质量。因此,法舒地尔注射液联合颈椎牵引治疗在椎动脉型颈椎病中值得广泛应用。

Objective:To investigate the effect of Fasudil Injection combined with cervical traction in the treatment of cervical spondylosis of vertebral artery type.Method:A total of 124 patients with cervical spondylosis of vertebral artery type admitted to Mubo Town Health Center of Huan County from January 2018 to January 2021 were randomly divided into two groups.The control group(n=62)was treated with Fasudil Injection,and the study group(n=62)was treated with cervical traction on the basis of the control group.The blood flow velocity,hemorheology index,quality of life,treatment effect and inflammatory factors of the two groups were compared.Result:After treatment,the blood flow velocity of right vertebral artery(RVA),basilar artery(BA)and left vertebral artery(LVA)in both groups increased significantly,and the indexes in the study group were faster than those in the control group(P<0.05).The levels of fibrinogen,high shear of whole blood viscosity,plasma viscosity and low shear of whole blood viscosity in both groups were significantly reduced,and the indexes in the study group were lower than those in the control group(P<0.05).The quality of life scores of both groups were significantly increased,and the score of the study group was higher than that of the control group(P<0.05).The total effective rates of the control group and the study group were 85.5%and 98.4%respectively,the study group was higher than that of the control group(P<0.05).The levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)in both groups decreased,and the levels in the study group were lower than those in the control group(P<0.05).Conclusion:Fasudil Injection combined with cervical traction in the treatment of patients with cervical spondylosis of vertebral artery type has ideal effect,which can improve the blood flow velocity,reduce the level of hemorheology and inflammatory factors,and improve the quality of life of patients.Therefore,Fasudil Injection combined with cervical traction is worthy of wide application in the treatment of cervical spondylosis of vertebral artery type.