胸腔镜下亚肺叶切除术治疗NSCLC患者的效果

Effect of Thoracoscopic Subpulmonary Lobectomy on NSCLC Patients

目的:探讨胸腔镜下亚肺叶切除术治疗非小细胞肺癌(NSCLC)患者的效果。方法:将汕头市第二人民医院胸外科2019年1月-2021年3月收治的85例NSCLC患者按随机数字表法分为对照组和观察组,对照组(42例)采用胸腔镜下肺叶切除术,观察组(43例)予以胸腔镜下亚肺叶切除术。观察两组手术情况、肺功能指标、免疫功能及并发症的发生情况。结果:观察组手术时间短于对照组,拔出引流管时间早于对照组,术中出血量、术后引流量少于对照组(P<0.05);观察组第1秒用力呼气容积(FEV;)、用力肺活量(FVC)、最大自主通气量(MVV)均大于对照组(P<0.05);观察组NK、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组(P<0.05);观察组并发症总发生率为6.98%,低于对照组的23.81%(P<0.05)。结论:胸腔镜下亚肺叶切除术治疗NSCLC患者可显著改善手术情况,提高免疫功能,促进肺功能恢复,且并发症发生率低。

Objective:To investigate the effect of thoracoscopic subpulmonary lobectomy in the treatment of non-small cell lung cancer(NSCLC).Method:A total of 85 patients with NSCLC treated in the department of Chest Surgery,Shantou Second People’s Hospital from January 2019 to March 2021 were divided into control group and observation group according to random numerical table method.The control group(42 cases)were treated with thoracoscopic lobectomy,and the observation group(43 cases)were treated with thoracoscopic subpulmonary lobectomy.The operation,pulmonary function,immune function and complications were observed between the two groups.Result:The operation time in the observation group was shorter than that in the control group,and the drainage tube pulling out time was earlier than that in the control group,the intraoperative blood loss and postoperative drainage were less than those in the control group(P<0.05).The forced expiratory volume in one second(FEV;),forced vital capacity(FVC)and maximum voluntary ventilation(MVV)in the observation group were greater than those in the control group(P<0.05).The levels of NK,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05).The total incidence of complications in the observation group was 6.98%,which was lower than 23.81%in the control group(P<0.05).Conclusion:Thoracoscopic subpulmonary lobectomy in the treatment of NSCLC patients can significantly improve the surgical situation,improve immune function,promote the recovery of lung function,and the incidence of complications is low.