小儿豉翘清热颗粒联合奥司他韦治疗儿童流行性感冒的Meta分析

A Meta-analysis of Child Chiqiao Qingre granules combined with Oseltamivir granules in the treatment of influenza in children

目的:系统评价小儿豉翘清热颗粒联合奥司他韦治疗儿童流行性感冒的临床疗效与安全性。方法:应用计算机检索万方数据库(Wan fang),中国期刊全文数据库(CNKI),维普数据库(VIP),中国医学文献数据库(SinoMed)、PubMed、Cochrane Library中相关文献,时间限定为从建库至2020年6月。搜集小儿豉翘清热颗粒联合奥司他韦治疗儿童流行性感冒的随机对照试验,由2名研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Revman5.3软件进行Meta分析。结果:共纳入16篇文献,2028例患儿。疗效方面:小儿豉翘清热颗粒联合奥司他韦治疗儿童流行性感冒优于单独应用奥司他韦治疗[风险率(Risk Rate,RR)=1.15,95%置信区间(Confidence Interval,CI)(1.12,1.19)],并可缩短发热[RR=-6.96,95%CI(-9.17,-4.76)]、鼻塞[MD=-15.29,95%CI(-23.9,-6.67)]、咽痛[MD=-9.92,95%CI(-12.13,-7.72)]、咳嗽[MD=-20.27,95%CI(-27.03,-13.51)]的痊愈时间及流感病毒检测恢复阴性时间[MD=-0.37,95%CI(-0.55,-0.20)],差异具有统计学意义。不良反应方面:小儿豉翘清热颗粒联合奥司他韦治疗具有较高的安全性[RR=0.50,95%CI(0.31,0.79)],差异具有统计学意义。结论:小儿豉翘清热颗粒联合奥司他韦治疗儿童流行性感冒可提高总有效率,缩短平均退热,咳嗽,咽痛,鼻塞,咳嗽,流感病毒检测恢复阴性时间,且安全性较高。但由于纳入研究的大多数文献质量较低,此结论仍需要大样本,高质量的随机对照研究来进一步验证。

Objective:To systematically evaluate the clinical efficacy and safety of Child Chiqiao Qingre granules(小儿豉翘清热颗粒)combined with Oseltamivir granules in treating influenza in children.Methods:The relevant literatures in Wanfang database,CNKI database,VIP database,SinoMed Database,PubMed and Cochrane Library were searched by computer.The retrieval time was from establishment of the database to June 2020.Randomized controlled trials were collected for the treatment of pediatric influenza with Child Chiqiao Qingre granules combined with Oseltamivir granules Two researchers independently screened literature,extracted data and evaluated the risk of bias in the included studies.Meta-analysis was performed using Revman5.3 software.A total of 16 literatures were included,including 2,028 children.Results:Inthe aspect of curative effect,the treatment of Child Chiqiao Qingre granules combined with Oseltamivir granules was better than the treatment with Oseltamivir alone[RR=1.15,95%CI(1.12,1.19)].And it can shorten the fever[risk rate(RR)=6.96,95%congfidence interval(CI)(9.17,4.76)],nasal congestion[mean difference(MD)=15.29,95%CI(23.9,6.67)],pharynx pain[MD=9.92,95%CI(12.13,7.72)],cough[MD=-20.27,95%CI(-27.03,-13.51)]recovery time and the recovery time of influenza virus negative test[MD=-0.37,95%CI(-0.55,-0.20)],the difference was statistically significant.In terms of adverse reactions:the treatment of Child Chiqiao Qingre granules combined with Oseltamivir granules showed high safety[RR=0.50,95%CI(0.31,0.79)],and the difference was statistically significant.Conclusion:Child Chiqiao Qingre granules combined with Oseltamivir granules can improve the total effective rate and shorten the average recovery time of fever,cough,sore throat,nasal congestion,cough and influenza virus test,and it is of high safety.However,due to the low quality of most of the included literatures,this conclusion still needs to be further verified by large sample and high-quality randomized controlled studies.