丹栀逍遥散合黄连温胆汤加减治疗失眠的效果及安全性分析

The effect and safety analysis of Danzhi Xiaoyao powder and Huanglian Wendan decoction in treating insomnia

目的:研讨失眠症患者采用丹栀逍遥散与黄连温胆汤加减治疗的临床疗效与安全性。方法:选择2019年1月-2020年1月就诊于中医科门诊的74例失眠症患者作为研究对象,按照随机数字表法设为两组,各37例,对照组患者接受艾司唑仑用药,每次服用2 mg,每日1次,观察组患者接受丹栀逍遥散合黄连温胆汤加减治疗,疗程均为4周,比较两组方案疗效、不良反应发生情况以及不同治疗时间段的睡眠质量。结果:观察组方案总有效率94.59%(35/37)略高于对照组81.08%(30/37),但比较无统计学意义(P>0.05)。治疗后,观察组入睡时间、睡眠时间以及睡眠效率等匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)各项得分明显低于对照组,差异有统计学意义(P<0.05)。观察组发生用药不良反应的总概率5.41%(2/37)明显低于对照组21.62%(8/37),组间差异有统计学意义(P<0.05)。结论:对失眠症患者采用丹栀逍遥散合黄连温胆汤加减治疗效果显著,可明显改善患者的睡眠状况,且该中医治疗方案不易引起不良反应,用药安全较有保障,值得推荐。

Objective:To investigate the clinical efficacy and safety of Danzhi Xiaoyao powder(丹栀逍遥散)and Huanglian Wendan decoction(黄连温胆汤)in the treatment of insomnia patients.Methods:between January 2019 and January 2020 in the regions of outpatient service of 74 cases of insomnia patients as the research object,set to two groups according to random number table method,the 37 cases,control group patients received estazolam medication,take 2 mg,once daily,observation group of patients accepted Dan Zhi xiaoyao powder and huanglian WenDan decoction subtraction treatment,a course of 4 weeks,compared two groups of curative effect and adverse reaction happening and the sleep quality of different treatment time.Results:the total effective rate in the observation group(94.59%,35/37)was slightly higher than that in the control group(81.08%,30/37),but there was no statistical significance(P>0.05).After treatment,the Pittsburgh sleep quality index(PSQI)scores of the observation group,such as sleep time,sleep time and sleep efficiency,were significantly lower than those of the control group,with statistically significant differences(P<0.05).The total probability of adverse drug reactions in the observation group(5.41%,2/37)was significantly lower than that in the control group(21.62%,8/37),and the difference between the two groups was statistically significant(P<0.05).Conclusion:Danzhi Xiaoyao powder combined with Huanglian Wendan decoction has a significant effect on insomnia patients,and can significantly improve the sleep status of patients,and the traditional Chinese medicine treatment scheme is not easy to cause adverse reactions,drug safety is more secure,is worthy of recommendation.