治疗前^(18)F-FDG PET/CT对胃MALT淋巴瘤的预测价值

The predictive value of pretreatment^(18)F-FDG PET/CT in gastric MALT lymphoma

目的:探讨治疗前行^(18)F-脱氧葡萄糖(^(18)F-fluorodeoxyglucose,^(18)F-FDG)正电子发射体层成像(positron emission tomography,PET)/计算机体层成像(computed tomography,CT)对胃黏膜相关淋巴样组织(mucosa-associated lymphoid tissue,MALT)淋巴瘤患者的疗效和预后的预测价值。方法:回顾并分析42例在治疗前行^(18)F-FDG PET/CT扫描的初诊胃MALT淋巴瘤患者。^(18)F-FDG PET/CT结果分析采用定性和半定量方法评估:视觉评估和最大标准摄取值(_(max)imal standard uptake value,SUV_(max))评估。以无进展生存期(progression-free survival,PFS)为终点评价预后。结果:随访患者13~80个月,平均(38.9±16.5)个月,PET阳性、高SUV_(max)与较差的PFS显著相关。多因素分析显示,SUV_(max)是PFS的唯一独立预测因子(HR=11.283,P=0.022)。SUV_(max)也可以独立预测疗效(OR=8.750,P=0.005)。结论:治疗前行^(18)F-FDG PET/CT可以预测胃MALT淋巴瘤患者的疗效和预后。

Objective:To investigate the predictive value of pretreatment^(18)F-fluorodeoxyglucose(^(18)F-FDG)positron emission tomography(PET)/computed tomography(CT)for treatment response and survival outcomes in gastric mucosa-associated lymphoid tissue(MALT)lymphoma patients.Methods:Forty-two patients with newly diagnosed gastric MALT lymphoma were retrospectively analyzed in this study.Each patient underwent^(18)F-FDG PET/CT scans before treatment.^(18)F-FDG PET/CT results were analyzed using qualitative and semi-quantitative assessment methods:visual assessment and_(max)imal standardized uptake value(SUV_(max)).Progression-free survival(PFS)was used as endpoints to evaluate prognosis.Results:Patients were followed for 13 to 80 months with a mean of(38.9±16.5)months.PET positivity and high SUV_(max)were significantly associated with inferior PFS.Multivariate analysis showed that SUV_(max)was the only independent predictor of PFS(HR=11.283,P=0.022).SUV_(max)could also independently predict the treatment response(OR=8.750,P=0.005).Conclusion:Pretreatment^(18)F-FDG PET/CT can predict treatment response and survival outcomes in gastric MALT lymphoma patients.