102例老年急性心肌梗死患者调脂药物使用情况分析

Analysis of the application of lipid-lowering drugs in 102 elderly patients with acute myocardial infarction

目的:了解我院心血管内科老年急性心肌梗死患者调脂药物的使用情况,为临床合理用药提供参考依据。方法:回顾性收集2020年1月1日–6月30日我院心血管内科收治的急性心肌梗死、年龄≥65岁的老年患者病历资料,参照药品说明书和相关诊疗指南,对其调脂药物使用的合理性进行分析和评价。结果:共纳入102例患者,所有患者初始治疗方案中均使用了他汀类药物,其中6例患者存在他汀类药物使用禁忌症。出院时95例患者使用了他汀类药物,4例单用依折麦布,3例未带调脂药物;5例(4.90%)用药不合理,其中存在用药禁忌症3例(2.94%),联合用药不合理1例(0.98%),遴选药品不适宜1例(0.98%)。结论:我院心血管内科老年急性心肌梗死患者调脂药物的使用基本符合相关指南的推荐,但仍存在少数不合理用药情况,应进一步加强对老年人肝肾功能的关注,确保老年患者用药安全有效。

Objective:To understand the use of lipid-lowering drugs in elderly patients with acute myocardial infarction(AMI)in our hospital,so as to provide references for rational drug use.Methods:Medical records of AMI patients aged≥65 years old who were admitted to the cardiovascular department in our hospital from January 1st,2020 to June 30th were retrospectively collected and the application of lipid-lowering drugs was statistically analyzed based on drug instructions and relevant diagnosis and treatment guidelines.Results:A total of 102 patients were included,and statins were applied in the initial treatment regimen for all patients.There were 6 patients who had contraindications to stains.When they left hospital,95 patients were continuously treated with statins,4 patients were treated with ezetimibe alone and 3 patients didn't take lipid-lowering drugs.There were 5 cases(4.90%)of irrational drug use,among which there were 3 cases(2.94%)with drug contraindications,1 case(0.98%)with unreasonable combination use of drugs,and 1 case(0.98%)with inappropriate drug.Conclusion:The use of lipid-lowering drugs for elderly AMI patients in the department of cardiovascular disease in our hospital basically met the recommendation of relevant guidelines while there were still a few cases of irrational drug use.We should pay more attentions to the liver and kidney function of the elderly in order to ensure the safety and effectiveness of drug use.