二尖瓣关闭不全对经导管主动脉瓣置换术的影响

Effect of mitral regurgitation on transcatheter aortic valve replacement

随着经导管主动脉瓣置换术(transcatheter aortic valve replacement,TAVR)指南适应证的不断扩大,临床中常遇到联合瓣膜病,现有相关研究表明术前伴有中-重度二尖瓣反流与较高的死亡率相关。在这些患者中,TAVR与循证心力衰竭治疗、TAVR与经导管二尖瓣介入联合治疗或分期经导管治疗的最佳治疗策略尚不明确。因此,对主动脉瓣和二尖瓣解剖和功能的全面评估,以及对患者基线风险状况的深入评估,是个体化治疗方法的基础。该文将综述报告相关研究结果,以期更好地帮助临床医生诊治相关患者。

With the expanding indications for transcatheter aortic valve replacement(TAVR) guidelines,combined valvular disease is often encountered in the clinic, and existing relevant studies have shown that preoperative moderate to severe mitral regurgitation is associated with higher mortality. In these patients, the optimal treatment strategy for TAVR with evidence-based heart failure, TAVR with transcatheter mitral intervention, or staging transcatheter therapy are unclear. Therefore, a comprehensive assessment of the anatomy and function of the aortic and mitral valves, as well as an in-depth assessment of the patient’s baseline risk profile, are the basis for an individualized approach to treatment. This article will review the results of the relevant research to better help clinicians diagnose and treat relevant patients.