过敏性咳嗽合并过敏性鼻炎患儿血清总IgE、外周血嗜酸性粒细胞、阳性过敏原种类与呼出气一氧化氮间的关系

Relationship between serum total IgE,peripheral blood eosinophils,positive allergen species and exhaled nitric oxide in allergic cough complicated with allergic rhinitis children

目的探讨过敏性咳嗽合并过敏性鼻炎患儿血清总免疫球蛋白E(IgE)、外周血嗜酸性粒细胞、阳性过敏原种类与呼出气一氧化氮间的关系。方法选取该院2018年1月至2021年4月收治的100例过敏性咳嗽合并过敏性鼻炎患儿为研究对象,进行皮肤点刺试验和血清总IgE、外周血嗜酸性粒细胞计数和百分比、呼出气一氧化氮水平检测。分析检出的阳性过敏原种类及分布情况;分析各类过敏原在不同性别患儿间的阳性率分布情况;比较不同致敏模式(多致敏组、单致敏组)下各指标水平;分析总IgE水平与阳性过敏原种类、呼出气一氧化氮水平、外周血嗜酸性粒细胞百分比及计数间的相关性。结果过敏性咳嗽合并过敏性鼻炎患儿中有33%仅检出单一过敏原阳性,26%检出2种过敏原阳性,41%检出3种及以上的过敏原阳性。不同性别患儿各类过敏原的阳性率差异无统计学意义(P>0.05)。多致敏组的血清总IgE水平高于单致敏组,差异有统计学意义(P<0.05)。血清总IgE水平与阳性过敏原种类、呼出气一氧化氮水平呈正相关(P<0.05),呼出气一氧化氮水平与外周血嗜酸性粒细胞百分比呈正相关(P<0.05),外周血嗜酸性粒细胞百分比与外周血嗜酸性粒细胞计数呈正相关(P<0.05)。结论多种过敏原阳性的过敏性咳嗽合并过敏性鼻炎患儿血清总IgE水平明显升高,总IgE水平、阳性过敏原种类、呼出气一氧化氮水平、外周血嗜酸性粒细胞之间具有一定的相关性,可为临床诊治提供参考。

Objective To investigate the relationship between serum total immunoglobulin E(IgE),peripheral blood eosinophils,positive allergen species and exhaled nitric oxide in allergic cough complicated with allergic rhinitis children.Methods A total of 100 children with allergic cough complicated with allergic rhinitis admitted to the hospital from January 2018 to April 2021 were selected as the research objects.The skin prick test and serum total IgE,percentage and count of peripheral blood eosinophils and exhaled nitric oxide were detected.Analyzed the species and distribution of positive allergens.Analyzed the distribution of positive rates of various allergens among children of different genders.Compared the index levels under different sensitization modes(multi-sensitization group,single-sensitization group).The correlation between serum total IgE level and positive allergen species,exhaled nitric oxide level,percentage and count of eosinophils in peripheral blood were analyzed.Results Only 33% of children with allergic cough complicated with allergic rhinitis were positive for a single allergen,26% were positive for two allergens,and 41%were positive for three or more allergens.There was no significant difference in the positive rates of various allergens in children of different genders(P>0.05).The serum total IgE level in the multi-sensitization group was higher than that in the single-sensitization group,and the difference was statistically significant(P<0.05).Serum total IgE level was positively correlated with positive allergen species and exhaled nitric oxide level(P<0.05),exhaled nitric oxide level was positively correlated with peripheral blood eosinophils percentage(P<0.05),peripheral blood eosinophils percentage was positively correlated with the peripheral blood eosinophils count(P<0.05).Conclusion The serum total IgE level in children with allergic cough complicated with allergic rhinitis positive for multiple allergens is significantly increased,and there is a certain correlation between the total IgE level,positive allergen species,the level of exhaled nitric oxide and eosinophils,which could provide some reference for clinical diagnosis and treatment.