下丘脑:运动改善骨代谢的关键控制器

Hypothalamus:the key controller for exercise-improved bone metabolism

背景:骨代谢一直都是骨组织工程研究的热点,研究发现下丘脑是运动改善骨代谢的主要调控中枢。目的:综述下丘脑在骨代谢中的作用,探讨运动介导下丘脑改善骨代谢的机制。方法:检索1983年1月至2021年12月CNKI和PubMed等中英文数据库,中文检索词:运动;下丘脑;骨代谢;英文检索词:exercise,hypothalamus,bone metabolism。选择下丘脑与骨代谢相关的文献以及运动介导下丘脑改善骨代谢的相关文献,对入选的72条文献进行归纳总结。结果与结论:①下丘脑作为调控机体生理活动的关键中枢,其下游的下丘脑-垂体-靶腺轴发挥了重要调控作用,影响神经肽Y、瘦素、骨钙素以及降钙素等激素的分泌,进而调控骨代谢调节因子和信号通路,改善骨质疏松等常见骨类疾病;②近年来,“脑-骨”串联介导的运动健骨作用受到医学、生物学和体育学研究领域的普遍关注,但其具体的发生和作用机制仍在探索中,运动通过机械力刺激和细胞内电信号的传导,激活骨代谢信号通路。

BACKGROUND:Bone metabolism has always been a hotspot in bone tissue engineering research.With the deepening of the mechanism,it has been found that hypothalamus is the main regulatory center for exercise to improve bone metabolism.OBJECTIVE:To review the role of hypothalamus in bone metabolism and to explo re the mechanism of exe rcise-mediated hypothalamus to improve bone metabolism.METHODS:A computer-based search of CNKI and PubMed databases was performed for relevant articles published from January 1983 to December 2021 with "exercise;hypothalamus;bone metabolism" as keywords both in Chinese and English.The documents that did not meet the inclusion criteria were excluded,and the 72 selected documents were summarized.RESULTS AND CONCLUSION:The hypothalamus is the key to regulating the body’s physiological activity and the downstream of the hypothalamus-pituitarytarget gland axis plays an important regulato ry roleto influence hormone secretion,such as neuropeptide Y,lepti n,osteocalcin and calcitonin,thus regulating regulatory factors and signaling pathways for bone metabolism,and further improving common bone diseases,such as osteoporosis.In recent years,the bonebuilding effect mediated by "brain-bone" crosstalk has received wides p read attention in medicine,biology and sports science,but its specific occurrence and mechanism of action are still under investigation.Exe rcise activates bone metabolic signaling pathways through mechanical fo rce stimulation and conduction of intracellular electrical signals.