过氧化物酶体增殖物激活受体PPAR在缺血性脑卒中作用的研究进展

Advances in effect of peroxisome proliferators-activated receptors in ischemic stroke

缺血性脑卒中(ischemia stroke,IS)是导致死亡和残疾的主要原因之一,具有高发病率和高复发率,目前临床仍缺乏有效的治疗方法。过氧化物酶体增殖物激活受体(peroxisome proliferators-activated receptors,PPARs)是一类配体激活的核转录因子,在多种生物学过程中发挥关键作用。近年的研究表明,PPARs与脑卒中关系密切。该文综述了近年来PPARs通过抑制神经炎症、氧化应激、凋亡、自噬、调控脱髓鞘、保护血脑屏障损伤、减轻脑水肿及调节乳酸代谢发挥抗IS的作用及其可能的作用机制,旨在为IS的预防及治疗提供新策略。

Ischemic stroke(IS)is one of the leading causes of mortality and disability with a high incidence and recurrence rate.However,effective therapy for treating IS is still unavailable in clinic.Peroxisome proliferation-activated receptors(PPARs)is a type of ligand-activated nuclear transcription factors that play a key role in a variety of biological processes.PPARs are close to IS,hence this study reviews that PPARs exerts the protective effect on IS through mediating neuroinflammation,oxidative stress,apoptosis,autophagy,demyelination,blood brain barrier function,encephaledema and lactic acid metabolism,which hopes to provide novel strategies for the prevention and treatment of IS.