老年胃癌患者术前纤维蛋白原、淋巴细胞与单核细胞比值对预后的影响

The effect of preoperative fibrinogen,lymphocyte to monocyte ratio on the prognosis of elderly patients with gas⁃tric cancer

目的探究老年胃癌患者术前纤维蛋白原(FIB),淋巴细胞/单核细胞比值(LMR)与预后的影响。方法回顾性研究126例60岁以上老年胃癌患者的临床病理资料,记录并计算所有患者的术前LMR和FIB值。将所有患者按LMR和FIB值分为LMR高FIB低、LMR高FIB高或者LMR低FIB低、LMR低FIB高三组,比较各组之间的临床病理学资料和3年无复发生存率。结果LMR≥4.19的老年胃癌患者3年无复发生存率比LMR<4.19的患者高(χ^(2)=16.21,P<0.05),FIB<2.74 g/L的老年胃癌患者3年无复发生存率比FIB≥2.74 g/L的患者高(χ^(2)=35.41,P<0.05)。LMR高FIB低组患者3年无复发生存率明显高于LMR低而FIB高的患者及LMR低FIB低与LMR高FIB高的患者,差异均有统计学意义(χ^(2)分别=52.30、42.64,P均<0.05)。结论FIB与LMR可作为一个易于获取的预测老年胃癌患者预后可靠指标。

Objective To explore the effects of fibrinogen(FIB),lymphocyte/monocyte ratio(LMR)and prognosis in elderly patients with gastric cancer.Methods The clinicopathological data of 126 elderly patients with gastric cancer over 60 years old were retrospectively studied,and the preoperative LMR and FIB values of all patients were recorded and calculated.All patients were divided into three groups according to high LMR low FIB,high LMR high FIB or low LMR low FIB,low LMR and high FIB,and the clinicopathological data and 3-year recurrence-free survival rate were compared among the groups.Results The three-year recurrence-free survival rate of elderly gastric cancer patients with LMR≥4.19 was higher than that of patients with LMR<4.19(χ^(2)=16.21,P<0.05).Patients with FIB<2.74 g/L had better prognosis compared with patients with FIB≥2.74 g/L(χ^(2)=35.41,P<0.05).Patients with high LMR and low FIB have the higher 3-year recurrence-free survival rate than patients with low LMR and high FIB,low LMR and low FIB,and high LMR and high FIB,the difference was statistically significant(χ^(2)=52.30,42.64,P<0.05).Conclusion FIB and LMR can be used as an easily accessible and reliable predictor of prognosis in elderly patients with gastric cancer.