超声引导下射频消融与手术治疗原发性甲状腺功能亢进症疗效比较

Efficacy of ultrasonic-guided radiofrequency ablation versus surgical resection in primary hyperthyroidism

目的比较超声引导下射频消融与手术治疗原发性甲状腺功能亢进症(甲亢)的疗效。方法35例原发性甲亢患者分别接受超声引导下射频消融治疗(n=13)或甲状腺次全切除术(n=22),比较两组术后当天疼痛分级、住院时间、疗效、甲状腺激素水平。结果射频组术后当天疼痛分级、住院时间低于手术组(P<0.01)。两组术后6个月疗效差异无统计学意义(P>0.05)。两组术后12个月甲状腺激素水平明显降低(P<0.01或0.05),促甲状腺激素水平明显升高(P<0.05)。结论超声引导下射频消融可减少原发性甲亢患者甲状腺素分泌,缩短住院时间,减轻术后疼痛。

Objective To compare the efficacy of ultrasound-guided radiofrequency ablation(US-RFA)and surgical resection in primary hyperthyroidism(PHT).Methods Thirty-fivePHT patients underwent US-RFA(n=13)or subtotal thyroidectomy(n=22).Pain grade on postoperative day,hospital stay,efficacy,and thyroid hormone levels were compared between two groups.Results Pain grade on postoperative day and hospital stay were lower in RFA group than in operation group(P<0.01).Six-month clinical efficacy was comparable between two groups(P>0.05).Serum thyroid hormone levels decreased(P<0.01 or 0.05),and thyroid-stimulating hormone content increased(P<0.05)12 months posttreatment in both groups.Conclusion US-RFA can reduce thyroxine secretion,shorten hospital stay and reduce postoperative pain in PHT patients.