钙-磷系自固化材料改性研究进展

Research Progress on Modification of Calcium-Phosphorus Self-Curing Material

由创伤、肿瘤和感染等原因引起的骨缺损通常面积较大,超过了骨自愈范围而不能自修复。因此,需要使用骨水泥对面积较大的骨缺损部位进行填充修复。磷酸钙水泥(calcium phosphate cement, CPC)是目前临床常用的一种骨水泥,可任意塑形,具有良好生物活性和生物相容性,近几十年来得到国内外学者的广泛研究。然而,从临床实践经验来看,CPC的应用范围有限,仍需要对其进行性能改进。本文主要分为两部分:在理化性能部分总结了CPC在力学强度、可注射性、抗溃散性和放射不透明性等四方面的改性方法;在生物学性能方面讨论了CPC成骨活性、生物可降解性和载药性方面的改性研究。

Bone defects caused by trauma, tumors, infections and other reasons are usually large in size, which exceed the self-healing range of bone and cannot be repaired by itself. Therefore, it is necessary to use bone cement to fill and repair bone defects. Calcium phosphate cement(CPC) is a kind of bone cement commonly used in clinical practice. Due to its plasticity, good bioactivity and biocompatibility, CPC has been widely studied by scholars at home and abroad in recent decades. However, in view of the perspective of clinical practice, the application scope of CPC is limited so that the performances of CPC need to be improved. This paper is mainly divided into two parts: in the part of physical and chemical properties, the modification methods of CPC in mechanical strength, injectability, anti-collapsibility and radiation opacity are summarized;in terms of biological properties, the modification of CPC in osteogenic activity, biodegradability and drug loading property are discussed.