乳糜泻病理机制研究进展

Research progress on pathological mechanism of celiac disease

乳糜泻(CD)的病理机制尚不完全明确,可能由环境因素触发遗传易感个体肠道内的炎症反应所致。近年研究表明,CD患者肠道黏膜屏障功能异常及肠道微生物改变等多因素的协同作用,可导致肠道内环境稳态失衡,进而加重疾病严重程度。去麦胶饮食配合益生菌等药物的治疗,能调节肠道微生物群,有利于肠道黏膜屏障功能的修复,可有效缓解CD患者的临床症状。但是肠道菌群的组成及其是否为CD诱因的证据尚待进一步考量。深入探究CD的病理机制,针对病理因素进行靶向治疗,是预防及精准诊疗CD的新方向。本文从遗传及环境因素等方面着手,对CD的病理机制进行综述。

The pathological mechanism of celiac disease is not completely clear,and environmental factors may trigger the occurrence of intestinal inflammatory response in genetic susceptible individuals.Recent researches indicated that,due to the coordinated action of multiple factors such as abnormal intestinal mucosal barrier function and intestinal microbial changes,the homeostasis of intestinal environment is imbalanced,which aggravates the severity of the disease.Gluten-free diet combined with probiotics and other drugs would regulate intestinal microbiota and be conducive to resume intestinal mucosal barrier function,thereafter effectively alleviate the clinical symptoms of patients.However,both the composition of intestinal flora and its role in pathogenesis of the disease needs further consideration.To explore the pathological mechanism of celiac disease and targeted treatment for those factors will become a new perspective for precise prevention and treatment of celiac disease.