肝纤维化相关信号通路及其相应的抗肝纤维化药物研究进展

Research advances in hepatic fibrosis related signal pathways and anti-hepatic fibrosis drugs

肝纤维化是肝脏长期受到各种急、慢性损伤导致肝星状细胞激活、细胞外基质生成与降解失衡并在肝脏沉积的一种病理学过程,受多条细胞信号转导通路和一系列细胞信息分子网络共同控制。如未行有效的治疗干预,随着病情的发展形成肝纤维结节并破坏正常的肝脏结构与功能,最终发展为肝硬化,出现肝功能的衰退,甚至演变为肝癌。本文着重介绍目前研究较明确和相对热点的肝纤维化信号通路、受体、非编码RNA及其对应的抗肝纤维化药物/分子的研究进展。

Hepatic fibrosis is a pathological process in which the liver is subjected to various acute and chronic injuries for a long time,resulting in activation of hepatic stellate cells,the imbalance between the production and degradation of extracellular matrix,and the deposition of extracellular matrix in the liver,and it is jointly controlled by multiple cellular signal transduction pathways and a series of cellular information molecular networks.If there is no effective treatment,with the progression of the disease,liver fibrous nodules will form,destroy normal liver structure and function,and finally develop into liver cirrhosis,the decline of liver function,and even liver cancer.This article summarizes the research advances in the signaling pathways,receptors,and non-coding RNAs involved in liver fibrosis and the corresponding anti-hepatic fibrosis drugs/molecules.