摘要
钠牛磺胆酸共转运多肽(NTCP)既是胆汁酸吸收入肝的重要转运体,又是HBV、HDV的功能性受体;其结构、功能、基因特点、表达调控机制等已得到广泛研究;且NTCP与慢性病毒性肝炎、非酒精性脂肪性肝病、肝纤维化、原发性胆汁性胆管炎、肝细胞癌相关,本文系统阐述了NTCP在各种肝胆疾病中的作用,为相关疾病的诊断及治疗提供新方向。
Sodium taurocholate cotransporting polypeptide(NTCP)is not only an important transporter for bile acid absorption into the liver,but also a functional receptor for HBV and HDV,and extensive studies have been performed for its structure,function,gene characteristics,and expression and regulation mechanisms.NTCP is also associated with chronic viral hepatitis,nonalcoholic fatty liver disease,liver fibrosis,primary biliary cholangitis,and hepatocellular carcinoma.This article elaborates on the role of NTCP in various hepatobiliary diseases,so as to provide new direction for the diagnosis and treatment of related diseases.
作者
高小强
左石
贾晓东
陆荫英
GAO Xiaoqiang;ZUO Shi;JIA Xiaodong;LU Yinying(Department of Hepatobiliary Surgery,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;Comprehensive Liver Cancer Center,The Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第5期1179-1182,共4页
Journal of Clinical Hepatology
基金
北京市自然科学基金面上项目(7212099)
深圳市科技创新委员会可持续发展专项(2019N002)
国家自然科学基金(81902495)
解放军总医院扶持项目(QNF19040)。
关键词
肝炎
病毒性
人
非酒精性脂肪性肝病
肝硬化
肝硬化
胆汁性
癌
肝细胞
钠牛磺胆酸共转运多肽
Hepatitis,Viral,Human
Non-alcoholic Fatty Liver Disease
Liver Cirrhosis
Liver Cirrhosis,Biliary
Carcinoma,Hepatocellular
Sodium Taurocholate Co-transporting Polypeptide
