外周血中性粒细胞数与淋巴细胞数比值、白细胞介素-6预测慢性鼻窦炎鼻内镜术后复发的价值

Value of neutrophil to lymphocyte ratio and interleukin-6 level in peripheral blood in predicting the recurrence of chronic rhino sinusitis after endoscopic sinus surgery

目的:探讨外周血中性粒细胞数与淋巴细胞数比值(NLR)、白细胞介素(IL)-6在预测慢性鼻窦炎(CRS)鼻内镜术后复发中的临床价值。方法:选择行鼻内镜术治疗的87例CRS病人作为研究对象,根据术后是否疾病复发分为术后复发组(n=30例)和术后未复发组(n=57例)。同期选择40名健康体检者作为对照组。采用全自动血生化仪检测各组外周血中性粒细胞、淋巴细胞水平,并计算NLR,同时采用酶联免疫吸附法检测各组外周血IL-6水平。比较各组中性粒细胞计数、淋巴细胞计数、NLR及IL-6水平,采用受试者工作特征曲线分析外周血NLR、IL-6单一和联合检测预测CRS鼻内镜术后复发的价值。结果:CRS病人中性粒细胞计数、NLR及IL-6水平均明显高于对照组(P<0.01),而淋巴细胞计数明显低于对照组(P<0.01);术后复发组中性粒细胞计数、NLR及IL-6水平均明显高于术后未复发组(P<0.01),而淋巴细胞计数明显低于术后未复发组(P<0.01);外周血NLR、IL-6联合检测的灵敏度、特异度及曲线下面积均明显优于外周血NLR、IL-6单一检测(P<0.01)。结论:外周血NLR、IL-6联合检测预测CRS鼻内镜术后复发具有较好的临床价值。

Objective:To explore the clinical value of neutrophil to lymphocyte ratio(NLR)and interleukin(IL)-6 level in peripheral blood in predicting the recurrence of chronic rhino sinusitis(CRS)after endoscopic sinus surgery.Methods:Eighty-seven patients with CRS treated with endoscopic sinus surgery were divided into the postoperative recurrence group(30 cases)and non-recurrence group(57 cases)according to the disease recurrence after surgery,and 40 healthy people were set as the control group at the same period.The levels of neutrophils and lymphocytes in peripheral blood in two groups were detected by automatic blood biochemical analyzer to calculate the NLR.Meanwhile,the levels of IL-6 in peripheral blood of each group were detected by enzyme-linked immunosorbent assay.The neutrophil count,lymphocyte count,NLR and IL-6 levels were compared between two groups.The receiver operating characteristic curve was used to analyze the value of single and combined peripheral blood NLR and IL-6 detection in predicting the recurrence of CRS after endoscopic sinus surgery.Results:The neutrophil count,NLR and IL-6 levels in CRS group were significantly higher than those in control group(P<0.01),while the lymphocyte count in CRS group was significantly lower than that in control group(P<0.01).The neutrophil count,NLR and IL-6 levels in recurrence group were significantly higher than those in non-recurrence group(P<0.01),while the lymphocyte count in recurrence group was significantly lower than that in non-recurrence group(P<0.01).The sensitivity,specificity and area under the curve of the combined detection of peripheral blood NLR and IL-6 were significantly better than those of single detection of peripheral blood NLR and IL-6(P<0.01).Conclusions:The combined detection of NLR and IL-6 in peripheral blood has good clinical values to predict the recurrence of CRS after endoscopic sinus surgery.