摘要
Dear Editor,Stem cell therapy holds enormous and revolutionary promise to treat various age-related diseases,such as diabetes,heart failure,and Parkinson’s disease.However,low retention and survival rate of delivered stem cells,partially due to immunological rejection,constitute major hurdles for the clinical implementation of stem cell therapy(Lei et al.,2021a).Since mounting evidence showed that several types of stem cells mainly exert their therapeutic effects through the secretion of paracrine effects,exosomes,which are released by stem cells and execute most paracrine functions,have begun to draw attention in the field(Tran and Damaser,2015).Exosomes are membrane-enclosed vesicles with an average diameter of∼100 nanometers secreted by the cells,containing cytokines.
基金
This work was supported by the National Key Research and Development Program of China(2020YFA0804000)
the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010000)
the National Key Research and Development Program of China(2018YFC2000100,2020YFA0112201,2017YFA0103304,2017YFA0102802,2018YFA0107203,2020YFA0803401,and 2019YFA0802202)
the National Natural Science Foundation of China(Grant Nos.81921006,81625009,91749202,81861168034,91949209,92049304,81822018,82071588,92049116,81801370,31801010,31970597,31901058 and U20A20403)
the Program of the Beijing Municipal Science and Technology Commission(Z191100001519005)
Beijing Natural Science Foundation(Z190019)
the Key Research Program of the Chinese Academy of Sciences(KFZD-SW-221)
K.C.Wong Education Foundation(GJTD-2019-06,GJTD-2019-08)
China Postdoctoral Science Foundation(2018M640154)
the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-JKCS011)
the Youth Innovation Promotion Association of CAS(2021078,E1CAZW0401)
the State Key Laboratory of Stem Cell and Reproductive Biology,the State Key Laboratory of Membrane Biology,and the Milky Way Research Foundation(MWRF).
