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内脂素在稳定性冠心病及ST段抬高性心肌梗死患者血清中表达水平的研究 被引量:1

Research on serum level of visfatin in patients with stable coronary artery disease and ST-segment elevation myocardial infarction
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摘要 目的:探讨血清内脂素水平与冠心病病情进展程度的相关性和对ST段抬高性心肌梗死(STEMI)的诊断意义。方法:入选中日友好医院心脏科2016年1月~2017年1月间41例稳定性冠心病(SCAD)患者、196例STEMI患者以及60例正常对照组患者,3组研究对象的外周动脉血清中内脂素表达水平的比较采用方差分析,内脂素与冠心病病情程度相关性采用Logistic回归分析,血清内脂素水平与STEMI诊断的相关性采用ROC曲线进行描述。结果:与正常对照组相比,SCAD组和STEMI组的血清内脂素水平均显著升高,且具有统计学意义(均P<0.01)。同时,STEMI组患者血清内脂素水平(9.1ng/ml)在3组中最高且具有统计学意义(P<0.01)。内脂素水平是冠心病患者发生STEMI的独立危险因素(OR:1.268,95%CI:1.138~1.413,P<0.01),外周血清内脂素水平诊断冠心病患者发生STEMI的曲线下面积为0.766(95%CI:0.695~0.837,P<0.01)。结论:内脂素可以作为一项有意义的生物学标志物来反映冠心病的发生及病情程度。同时,外周血内脂素水平的升高可以作为STEMI发生的一个有效的诊断学指标。 Objective:To explore the correlation and diagnostic significance between serum visfatin level and the progression of coronary heart disease.Methods:A total of 41 patients with stable coronary artery disease(SCAD),196 patients with ST-segment elevation myocardial infarction(STEMI),and 60 healthy controls were enrolled in this study from the Department of Cardiology,China-Japan Friendship Hospital between January2016 and January 2017.Comparisons of the visfatin level were performed by analysis of variance,the correlation between visfatin and the progression of coronary heart disease was analyzed by logistic regression,and the correlation between visfatin level and diagnosis were performed by ROC curve.Results:The levels of visfatin in SCAD group and STEMI group were significantly higher compared with the normal control group(P<0.01).The level of visfatin in STEMI group(9.1ng/ml)was the highest among the three groups(P<0.01).The level of visfatin was the independent risk factor of STEMI among patients with coronary heart disease(OR:1.268,95%CI:1.138~1.413,P<0.01).The AUC of ROC curve in visfatin level for the STEMI diagnosis in patients with coronary heart disease was 0.766(95%CI:0.695~0.837,P<0.01).Conclusion:Visfatin can be used as a meaningful biomarker to reflect the occurrence and the progression of coronary heart disease.More importantly,the circulating visfatin is an effective diagnostic biomarker for STEMI.
作者 董哲 刘晓飞 张虎 王放 李菁 DONG Zhe;LIU Xiao-fei;ZHANG Hu(Department of Cardiology,China-Japan Friendship Hospital,Beijing 100029,China)
出处 《中日友好医院学报》 CAS 2022年第2期67-70,共4页 Journal of China-Japan Friendship Hospital
基金 国家自然基金青年科学基金(81500286)。
关键词 内脂素 ST段抬高性心肌梗死 诊断学标志物 visfatin ST-segment elevation myocardial infarction diagnostic marker
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