摘要
BACKGROUND Coronavirus disease 2019(COVID-19)is a highly contagious viral illness which conventionally manifests with primarily respiratory symptoms and less commonly with cardiac involvement in various forms,such as pericarditis.Myocarditis and pericarditis have been reported in a variety of live and attenuated vaccines,such as smallpox and influenza.As of October 2021,no cases of pericarditis associated with COVID-19 vaccination have been published.We present two healthy male patients who present post COVID-19 vaccination with pericarditis diagnoses.CASE SUMMARY A 21-year-old male with no significant past medical history presented with myalgia,chills,mild headache,and chest pain for two days.Patient received the Moderna COVID-19 vaccine the day prior to symptom onset.On presentation,electrocardiogram(ECG)revealed sinus rhythm with ST elevation,and troponin was elevated.Emergent cardiac catheterization was not significant for abnormalities.The primary diagnosis was acute pericarditis,and the patient was discharged on colchicine and indomethacin.Additionally,a 35-year-old male with no pertinent past medical history presented with fever,chills,weakness,nausea,vomiting,diarrhea,and retrosternal chest pain for three days.He received the Moderna COVID-19 vaccine four days prior to symptom onset.On presentation,troponin was elevated,and ECG revealed mild ST elevation.Left ventricular dysfunction with ejection fraction of 41%was reported on transthoracic echocardiogram.Patient was started on ibuprofen and colchicine for diagnosis of myopericarditis.CONCLUSION These case reports highlight a potential unintended consequence,pericarditis,associated with COVID-19 vaccination that may not warrant invasive cardiac intervention.
