2017—2020年儿科鼠伤寒沙门菌的分离及耐药情况分析

Isolation and drug resistance analysis of Salmonella typhimurium in pediatrics from 2017 to 2020

目的分析2017—2020年儿科鼠伤寒沙门菌的分离及耐药情况,为临床合理选择抗生素提供依据。方法对115例腹泻患儿的肛拭样本(分离后确诊为沙门菌)进行分离培养,在生化鉴定和血清学分型确定为鼠伤寒沙门菌后采用Kirby-Bauer纸片扩散法进行抗菌药物敏感性试验,并采用Whone5.6及SPSS21.0软件包进行数据统计及分析。结果2017—2020年共有115例患儿经血清型鉴定检出鼠伤寒沙门菌。鼠伤寒沙门菌高发于夏秋季节,占84.35%。感染患儿以<3岁幼儿为主。鼠伤寒沙门菌对氨苄西林及头孢曲松的平均耐药率比较高,而对喹诺酮类药物以及头孢哌酮/舒巴坦的敏感性高。结论鼠伤寒沙门菌对氨苄西林和头孢曲松的耐药率高,临床应合理选择抗生素,避免细菌耐药的发生。

Objective To analyze the isolation and drug resistance of Salmonella typhimurium in pediatrics from 2017 to 2020,in order to provide evidence for rational selection of antibiotics.Methods The anal swab samples of 115 children with diarrhea confirmed to be Salmonella after isolation were isolated and cultured.After Salmonella typhimurium were determined by biochemical identification and serum typing,the antimicrobial sensitivity test was carried out by Kirby-Bauer disk diffusion method.Whonet5.6 and SPSS21.0 software packages were used for data statistics and analysis.Results From 2017 to 2020,Salmonella typhimurium was detected in 115 children through serotype identification.Salmonella typhimurium was highly prevalent in summer and autumn,accounting for 84.35%.The majority of infected children were<3 years old.The average resistance rates of Salmonella typhimurium to ampicillin and ceftriaxone were relatively high,while its sensitivity to quinolone drugs and cefoperazone/sulbactam was high.Conclusion The Salmonella typhimurium to ampicillin and ceftriaxone has high resistance rate.Antibiotics should be reasonably selected in clinic to avoid the occurrence of bacterial resistance.