Caprini评分联合D-二聚体、LPA对术后深静脉血栓形成的诊断价值

Diagnostic value of Caprini score combined with D-dimer and LPA for postoperative deep venous thrombosis

目的分析Caprini评分联合D-二聚体、溶血磷脂酸(LPA)对术后深静脉血栓形成(DVT)的诊断价值。方法选择我院2019年1月至2020年11月收治的163例术后患者作为研究对象,将术后发生DVT的55例患者设为DVT组,未发生DVT的108例患者设为非DVT组。对两组患者进行Caprini血检风险评分,检测血浆D-二聚体、LPA水平,并比较两组的检测结果。结果两组患者的年龄、BMI、WBC、ALT、AST、PT、APTT、CRE、Urea及性别比较,差异无统计学意义(P>0.05);两组患者的卧床时间、Hcy比较,差异具有统计学意义(P<0.05)。两组的低危、中危、高危患者占比比较,差异无统计学意义(P>0.05);两组的极高危患者占比比较,差异具有统计学意义(P<0.05)。Caprini评分、D-二聚体、LPA诊断DVT的灵敏度分别为66.20%、67.41%、74.40%,特异度分别为63.52%、70.94%、80.51%,AUC分别为0.704、0.797、0.794;Caprini评分、D-二聚体、LPA三者联合诊断DVT的灵敏度为64.32%、特异度为87.40%、AUC为0.887。结论Caprini评分联合D-二聚体、LPA有利于DVT的早期诊断,具有一定的临床应用价值。

Objective To analyze the diagnostic value of Caprini score combined with D-dimer and lysophosphatidic acid(LPA)for postoperative deep venous thrombosis(DVT).Methods A total of 163 postoperative patients treated in our hospital from January 2019 to November 2020 were selected as the research objects,of which 55 patients with postoperative DVT were set as DVT group and 108 patients without postoperative DVT were set as non-DVT group.The risk of Caprini thrombosis was assessed in both groups,the levels of plasma D-dimer and LPA were detected,and the test results of the two groups were compared.Results There were no significant differences in age,BMI,WBC,ALT,AST,PT,APTT,CRE,Urea and gender between the two groups(P>0.05);there were statistically significant differences in bed time and Hcy between the two groups(P<0.05).There was no significant difference in the proportion of low-risk,medium-risk and high-risk patients between the two groups(P>0.05);there was significant difference in the proportion of very high-risk patients between the two groups(P<0.05).The sensitivity of Caprini score,D-dimer and LPA in the diagnosis of DVT were 66.20%,67.41%and 74.40%respectively,the specificity were 63.52%,70.94%and 80.51%respectively,and the AUC were 0.704,0.797 and 0.794 respectively;the sensitivity,specificity and AUC of Caprini score,D-dimer combined with LPA were 64.32%,87.40%and 0.887 respectively.Conclusion Caprini score combined with D-dimer and LPA is conducive to the early diagnosis of DVT and has certain clinical application value.