前列地尔联合腺苷蛋氨酸治疗病毒性肝炎合并高胆红素血症的临床效果及对肝功能指标的影响

Clinical effect of alprostadil combined with adenosylmethionine in the treatment of viral hepatitis complicated with hyperbilirubinemia and its effect on liver function indexes

目的探究与分析前列地尔联合腺苷蛋氨酸治疗病毒性肝炎合并高胆红素血症的效果及对肝功能指标的影响。方法选择2018年8月至2020年8月我院收治的90例病毒性肝炎合并高胆红素血症患者为研究对象,按照随机数字表法将患者分为对照组与观察组,每组45例。两组均给予常规药物治疗,对照组在此基础上采用前列地尔治疗,观察组在对照组基础上加用腺苷蛋氨酸治疗,两组均连续治疗4周。比较两组的临床疗效、肝功能指标[血清总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)、总胆汁酸(TBA)、白蛋白(ALB)、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)]水平、不良反应发生情况及不良情绪评分。结果观察组的治疗总有效率为95.56%,显著高于对照组的80.00%(P<0.05)。治疗后,两组患者的TBIL、DBIL、TBA、GGT、ALP水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的各项不良反应发生率比较,差异均无统计学意义(P>0.05)。治疗后,两组患者的SAS、SDS评分均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。结论前列地尔联合腺苷蛋氨酸治疗病毒性肝炎合并高胆红素血症的效果显著,能够有效改善患者的肝功能及负性情绪,且无明显不良反应,安全性较高,值得临床推广应用。

Objective To explore and analyze the effect of alprostadil combined with adenosylmethionine in the treatment of viral hepatitis complicated with hyperbilirubinemia and its effect on liver function indexes.Methods Ninety patients with viral hepatitis complicated with hyperbilirubinemia treated in our hospital from August 2018 to August 2020 were selected as research objects and divided into control group and observation group according to the random number table method,with 45 cases in each group.Both groups were given routine drug treatment,the control group was treated with alprostadil on this basis,and the observation group was given adenosylmethionine on the basis of the control group.Both groups were treated continuously for 4 weeks.The clinical efficacy,levels of liver function indexes[serum total bilirubin(TBIL),direct bilirubin(DBIL),alanine aminotransferase(ALT),total bile acid(TBA),albumin(ALB),glutamyltranspeptidase(GGT),alkaline phosphatase(ALP)],occurrence of adverse reactions and adverse emotion scores were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.56%,which was significantly higher than 80.00%in the control group(P<0.05).After treatment,the levels of TBIL,DBIL,TBA,GGT and ALP in patients of the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,there were no significant differences in the incidences of various adverse reactions between the two groups(P>0.05).After treatment,the SAS and SDS scores of the patients in two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion Alprostadil combined with adenosylmethionine in the treatment of viral hepatitis complicated with hyperbilirubinemia has a significant effect,it can effectively improve liver function and adverse emotion of patients,without obvious adverse reaction,has higher safety,which is worthy of clinical popularization and application.