他克莫司血药浓度与中国人肾小球疾病临床疗效及不良反应的相关性研究

Study on correlation between tacrolimus plasma concentration with clinical efficacy and adverse reaction in Chinese patients with glomerular disease

目的:分析他克莫司血药浓度与肾小球疾病疗效及不良反应的关系。方法:检索万方数据库、知网、维普中文数据库,收集他克莫司血药浓度与肾小球疾病临床疗效及不良反应的相关性研究,纳入符合标准的文献,提取有效数据,采用SPSS(24.0)统计学软件进行分析,比较不同血药浓度范围的他克莫司与肾小球疾病患者的疗效及不良反应的关系。结果:共纳入4篇文献,统计学分析结果显示他克莫司血药浓度与肾小球疾病疗效具有统计学意义上的相关性(P=0.011)。他克莫司血药浓度越高不良反应发生率越高。结论:他克莫司血药浓度与肾小球疾病临床疗效及不良反应具有相关性,临床上应将他克莫司血药浓度控制在适当范围以增加疗效同时减少不良反应,实现个体化治疗。

Objective:To analyze the relationship between tacrolimus plasma concentration and the effect and adverse reactions in glomerular diseases patients.Methods:Wanfang database,CNKI and VIP Chinese database were retrieved to collect studies on the correlation between tacrolimus plasma concentration and the effect and adverse reactions in glomerular diseases patients.Literature that met the inclusion standards was included,effective data were extracted,and SPSS(24.0)statistical software was used for the correlation analysis.Results:Four studies were included,and statistical analysis showed a statistically significant correlation between tacrolimus plasma concentration and the efficacy in glomerular disease patients(P=0.011).The higher the concentration of tacrolimus was,the higher the incidence of adverse reactions was.Conclusion:The plasma concentration of tacrolimus is correlated with the clinical efficacy and adverse reactions in glomerular diseases patients.It is necessary to control tacrolimus plasma concentration in an appropriate range to improve the efficacy and reduce adverse reactions,and realize individualized treatment.