摘要
肠道微生物是寄居在人体肠道中、与人体共生的庞大群体,是人类的第二基因库。近年来关于肠道微生物与机体健康和疾病之间关系及相互作用的研究兴起,并得到快速发展。肠道微生物可介导机体健康状况和病理进程的诸多方面,如骨的生长发育和骨疾病。研究发现,肠道微生物可通过影响机体的代谢活动、免疫机能、内分泌等途径调节骨稳态,介导骨健康,但其深层机制尚不明确。深入探讨肠道微生物在骨稳态与骨健康中的作用机制具有重要意义,可为研究肠道微生物与骨稳态和骨健康,以及骨退行性疾病之间的关系提供新的视角。
Gut microbiota is a large group living in human intestines and symbiotic with human body.They are the second gene pool of human beings.In recent years,the research on the relationship and interaction between gut microbiota and health and disease has been developed rapidly.Gut microbiota can mediate many aspects of the health and pathological process,such as bone growth and bone diseases.It has been found that gut microbiota can regulate bone homeostasis by influencing metabolic activity,immune function,endocrine,and other pathways,but the underlying mechanism is not clear.It is of great significance to further explore the mechanism of gut microbiota in bone homeostasis and bone health,which can provide a new perspective for the study of the relationship between gut microbiota and bone homeostasis,bone health,as well as bone degenerative diseases.
作者
余锋
贾芳芳
YU Feng;JIA Fang-fang(Social Sports Guidance and Management Department,Institute of Physical Education, Huaiyin Normal University,Huaian 223300, Jiangsu, China;Public Physical Education Teaching Department,Institute of Physical Education,Huaiyin Normal University,Huaian 223300, Jiangsu, China;School of Physical Education,Soochow University,Suzhou 215021, Jiangsu, China)
出处
《中华骨质疏松和骨矿盐疾病杂志》
CSCD
北大核心
2022年第1期74-81,共8页
Chinese Journal Of Osteoporosis And Bone Mineral Research
基金
教育部人文社会科学研究青年基金(19YJC890056)
江苏省高校自然科学研究面上项目(16KJD180001)。
关键词
肠道微生物
骨稳态
骨健康
gut microbiota
bone homeostasis
bone health
