奥扎格雷钠的合成工艺研究

Study on Synthesis Technology of Sodium Ozagrel

目的针对现有合成工艺的不足,找到一种较为安全环保、生产成本较低、易于操作、溶剂可回收利用、适合工业化的奥扎格雷钠的制备方法。方法分别以甲基肉桂酸甲酯与咪唑钠为起始原料,对反应物料配比、溶剂的选择、反应温度、反应时间、后处理方式、产品纯化等条件进行工艺研究。结果该方法制备的奥扎格雷钠符合质量标准。结论确定该生产工艺合理可行,并获得工艺最佳生产条件,便于生产。

Objective In response to the deficiency of existing synthesis process,to explore an industrial preparation of sodium ozagrel,which features safe and environmental protection,low production cost,easy operation,and recycle of solvent.Methods Methyl cinnamate and sodium imidazolate were used respectively as the starting materials.The reaction material ratio,solvent selection,reaction temperature,reaction time,post-treatment method and product purification and other conditions were studied.Results The sodium ozagrel prepared by this method can meet the quality standard.Conclusion The production process has been determined to be reasonable and feasible,and the optimal production conditions have been obtained,which are convenient for production.