摘要
BACKGROUND The resulting tissue hypoxia and increased inflammation secondary to severe coronavirus disease 2019(COVID-19)combined with viral load,and other baseline risk factors contribute to an increased risk of severe sepsis or co-existed septic condition exaggeration.AIM To describe the clinical,radiological,and laboratory characteristics of a small cohort of patients infected by severe acute respiratory syndrome coronavirus 2 who underwent percutaneous drainage for septic complications and their postprocedural outcomes.METHODS This retrospective study consisted of 11 patients who were confirmed to have COVID-19 by RT-PCR test and required drain placement for septic complications.The mean age±SD of the patients was 48.5±14 years(range 30-72 years).Three patients underwent cholecystostomy for acute acalculous cholecystitis.Percutaneous drainage was performed in seven patients;two peripancreatic collections;two infected leaks after hepatic resection;one recurrent hepatic abscess,one psoas abscess and one lumbar abscess.One patient underwent a percutaneous nephrostomy for acute pyelonephritis.RESULTS Technical success was achieved in 100%of patients,while clinical success was achieved in 4 out of 11 patients(36.3%).Six patients(54.5%)died despite proper percutaneous drainage and adequate antibiotic coverage.One patient(9%)needed operative intervention.Two patients(18.2%)had two drainage procedures to drain multiple fluid collections.Two patients(18.2%)had repeat drainage procedures due to recurrent fluid collections.The average volume of the drained fluid immediately after tube insertion was 85 mL.Follow-up scans show a reduction of the retained content and associated inflammatory changes after tube insertion in all patients.There was no significant statistical difference(P=0.6 and 0.4)between the mean of WBCs and neutrophils count before drainage and seven days after drainage.The lymphocyte count shows significant increased seven days after drainage(P=0.03).CONCLUSION In this study,patients having septic complications associated with COVID-19 showed relatively poor clinical outcomes despite technically successful percutaneous drainage.
