0.1%他克莫司软膏联合青鹏软膏治疗阴囊湿疹的临床疗效观察

Observation of the clinical effects of 0.1%tacrolimus ointment combined with Qingpeng ointment on the treatment of scrotal eczema

目的观察0.1%他克莫司软膏联合青鹏软膏治疗阴囊湿疹的有效性,分析该治疗方案的临床疗效及对患者生活质量的影响。方法门诊就诊的69例阴囊湿疹患者分成两组,均口服依巴斯汀片20 mg,1次/d,对照组34例使用0.1%他克莫司软膏治疗,每日2次,治疗组35例在对照组基础上加用青鹏软膏治疗,每日2次,对比两组患者的治疗效果。结果治疗前,2组生活质量评分(DLQI)、症状积分(EASI)差异无统计学意义(P>0.05);治疗后,治疗组的症状改善时间、EASI、DLQI、治疗优良率、复发率均优于对照组,差异具有统计学意义(P<0.05)。结论0.1%他克莫司软膏联合青鹏软膏治疗阴囊湿疹,可提高患者治疗有效性、改善生活质量,效果优于单用0.1%他克莫司软膏。

Objective To analyze the clinical effectiveness of 0.1%tacrolimus ointment combined with Qingpeng ointment for patients with scrotal eczema and its effects on patients quality of life.Methods 69 cases of scrotal eczema outpatients treated in our department were enrolled.All of them were treated with oral ebastine tablets 20 mg/d.They were randomly divided into two groups,34 patients in the control group were treated with pure 0.1%tacrolimus ointment,twice a day,and 35 patients in the treatment group were treated with 0.1%tacrolimus ointment,twice a day,combined with Qingpeng ointment,twice a day.The treatment effects of the two groups were compared.Results Before treatment,there were no significant differences in dermatology life quality index(DLQI)and eczema area and severity index(EASI)between the two groups(P>0.05).After treatment,the symptoms improvement time,EASI,DLQI,excellent treatment rate,and recurrence rate of patients in the treatment group were significantly better than those in the control group(P<0.05).Conclusions For patients with scrotal eczema,0.1%tacrolimus ointment combined with Qingpeng ointment could improve the treatment effectiveness and the quality of life,and the clinical effectiveness was better than 0.1%tacrolimus ointment alone.