蛹虫草微胶囊的制备及工艺优化

Preparation and Process Optimization of Cordyceps militaris Microcapsule

微胶囊是近年来在保健食品领域应用较广的技术,而乳化-固化法是制备具有生物降解性天然高分子微胶囊的途径之一,操作简便,成本低。本研究以腺苷的包埋率为指标,利用正交试验设计,优化乳化-固化法制备蛹虫草微胶囊工艺。结果表明,当壁材比(抗性淀粉/海藻酸钠,W/V)为1.5%、芯壁比(蛹虫草提取液/海藻酸钠,V/V)为1∶200、转速为2000 r·min^(-1)、氯化钙用量(海藻酸钠/氯化钙,V/V)为20∶11和乳化时间为70 min时,功效成分的包埋率最高,且微胶囊成品的外观形貌良好。研究成果的应用,可为保健食品缓释制剂产业的发展提供技术支持。

Microcapsule is a widely used technology in the field of health food in recent years,and emulsification solidification method is one of the ways to prepare biodegradable natural polymer microcapsules with simple operation and low cost.In this study,the entrapment rate of adenosine was used as an index and an orthogonal experimental design was used to optimize the preparation of Cordyceps militaris microcapsules by the emulsification curing method.The results showed that when the wall material ratio(resistant starch/sodium alginate,W/V)was 1.5%,the core wall ratio(Cordyceps militaris extract/sodium alginate,V/V)was 1∶200,the rotating speed was 2000 r·min^(-1),the dosage of calcium chloride(sodium alginate/calcium chloride,V/V)was 20∶11,and the emulsification time was 70 min,the embedding rate of functional components was the highest,and the appearance of the finished microcapsule was good.The application of the research results can provide technical support for the development of health food sustained-release preparation industry.