血清Cys-C、UA、CD4^(+)、CD8^(+)与脑梗死颅内动脉狭窄的关系及影响因素分析

The relationship and influencing factors between serum Cys-C,UA,CD4^(+) and CD8^(+) and intracranial artery stenosis in cerebral infarction and analysis of influencing factors

目的探究血清胱抑素C(Cys-C)、尿酸(UA)、CD4^(+)T细胞和CD8^(+)T细胞与脑梗死颅内动脉狭窄的关系及影响因素分析。方法收集2020年6月-2021年9月在我院住院的124例脑梗死患者的临床资料,患者均完成头部MRA或/和CTA及常规生化检查。根据颅内大血管近端狭窄程度分为无狭窄组(36例)、轻度狭窄组(43例)及中重度狭窄组(45例)。比较3组患者临床资料及血清Cys-C、UA、T细胞亚群差异,并以多元Logistic回归分析脑梗死颅内动脉狭窄的影响因素,以ROC曲线评估血清Cys-C、UA、T细胞亚群对脑梗死颅内动脉狭窄的价值。结果血清Cys-C、UA水平及CD4^(+)T细胞水平无狭窄组<轻度狭窄组<中重度狭窄组,与脑梗死颅内动脉狭窄均呈正相关;血清CD8^(+)T细胞水平无狭窄组>轻度狭窄组>中重度狭窄组,与脑梗死颅内动脉狭窄程度呈负相关。结论血清Cys-C、UA、CD4^(+)T细胞升高及CD8^(+)T细胞降低为脑梗死颅内动脉狭窄的危险因素,且随颅内动脉狭窄程度的加重,血清CysC、UA、CD4^(+)T细胞升高,CD8^(+)T细胞降低。

Objective To explore the relationship between serum cystatin C(Cys-C),uric acid(UA),CD4^(+)T cells and CD8^(+)T cells with intracranial artery stenosis and cerebral infarction and analyze their influencing factors.Methods The clinical data of 124 patients with cerebral infarction who were hospitalized in our hospital from June 2020 to September 2021 were collected.All patients were given Brain MRA or/and CTA and routine biochemical examinations.According to the degree of proximal stenosis of intracranial large vessels,patients were divided into no stenosis group(36cases),mild stenosis group(43 cases),and moderate to severe stenosis group(45 cases).The clinical data of the three groups of patients and the differences in serum Cys-C,UA,and T cell subsets were compared.The factors affecting intracranial artery stenosis in cerebral infarction were analyzed by multivariate Logistic regression.The ROC curve was used to evaluate the value of serum CysC,UA and T cell subsets in patients with the cerebral infarction intracranial artery stenosis narrow.Results The serum levels of Cys-C,UA,CD4^(+)T cells were lower in no stenosis group than those in mild stenosis group and those in medium-severe stenosis group,and positively correlated with cerebral infarction intracranial artery stenosis.The serum levels of CD8^(+)T cells were higher in no stenosis group than those in mild stenosis group and those in medium-severe stenosis group,and were negatively correlated with cerebral infarction intracranial artery stenosis.Conclusion The increase of serum Cys-C,UA,CD4^(+)T cells and the decrease of CD8^(+)T cells are risk factors for intracranial artery stenosis in cerebral infarction.As the degree of intracranial artery stenosis worsens,Cys-C,UA,CD4^(+)T cells increase,and CD8^(+)T cells decrease.