中性粒细胞/淋巴细胞比值在多发性硬化和视神经脊髓炎谱系疾病中的鉴别诊断价值

The clinical value of Neutrophil to lymphocyte ratio in differentiating multiple sclerosis and neuromyelitis optica spectrum disorders

目的探究中性粒细胞/淋巴细胞比值(NLR)在多发性硬化(MS)、视神经脊髓炎谱系疾病(NMOSD)和健康人间的差异,并分析NLR在鉴别诊断方面的临床价值。方法回顾性分析2017年-2021年就诊于中国医科大学附属盛京医院的初诊MS患者和NMOSD患者,并收集临床资料、生化检查、计算NLR。选择年龄、性别匹配的50名健康体检者作为对照组。结果中性粒细胞、淋巴细胞、单核细胞、NLR在MS、NMOSD和健康对照间存在明显差异。NLR在MS和NMOSD鉴别中的受试者工作曲线下面积(AUC)为0.796(P<0.001,95%CI 0.685~0.907)。结论MS患者NLR水平高于健康对照组,但低于NMOSD患者。NLR可用于MS和NMOSD的鉴别。

Objective To explore the difference of Neutrophil to lymphocyte ratio(NLR)among multiple sclerosis(MS),neuromyelitis optica spectrum disorders(NMOSD),and healthy people,and analyze the clinical value in differentiating MS and NMOSD.Method Clinical data and laboratory results from patients admitted to Shengjing hospital who were diagnosed with MS or NMOSD,and calculate NLR were retrospectively analyzed.Fifty healthy people matched with sex and age were selected as controls.Result There were significant differences of neutrophils,lymphocyte,monocyte and NLR among MS,NMOSD and healthy people.The area under curve of ROC in differentiating MS and NMOSD was 0.796(P<0.001,95%CI 0.685~0.907).Conclusion The NLR of patients with MS was higher than healthy control,but lower than NMOSD.And NLR was a helpful marker to differentiate MS and NMOSD.