影响心脏瓣膜钙化的因素及相关分子机制研究进展

Research on the affecting factors and molecular mechanisms of cardiac valve calcification

心脏瓣膜钙化是由多种分子机制共同参与的复杂病理过程,发病率随年龄增长而上升,瓣膜间质细胞表型分化过程是瓣膜钙化的关键环节。脂质代谢异常作为瓣膜钙化的独立危险因素,在瓣膜局部形成损伤并诱导炎症反应,产生的炎症因子可以促进瓣膜间质细胞发生表型分化。非编码RNA可以从多方面调控炎症反应和成骨分化,影响瓣膜间质细胞表型分化进程,参与心脏瓣膜钙化的发生。

Cardiac valve calcification(CVC) is a complex pathological process which involves several molecular mechanisms,and its incidence increases with age.The redifferentiation of valvular interstitial cells(VICs) is the key of CVC.AS the independent risk factor for CVC,dyslipidemia can cause the local injury and induce the inflammatory response.The inflammatory factors produced can promote the phenotypic differentiation of valve interstitial cells.The non-coding RNAs which regulate the expression of genes involved in inflammatory and osteogenic differentiation can affect the differentiation of VICs,are the undeniable regulators of CVC.