血压昼夜节律与靶器官损伤及时间治疗学

Circadian rhythm of blood pressure and target organ injury and chronotherapy

高血压在临床上是一种比较常见的心血管疾病,近年来患病率不断增长,危害着人类的健康,给家庭和社会造成了极大的负担。研究表明,高血压对心脏、脑、肾等靶器官的损伤不仅与血压水平有关,还与血压昼夜节律有关。高血压时间治疗学通过血压节律特点调整给药时间,使血压恢复正常的昼夜节律,对高血压患者进行最佳治疗。本文就血压昼夜节律、靶器官损伤及时间治疗学做一综述。

Hypertension is a common cardiovascular disease in clinical practice.In recent years,its prevalence is increasing,which endangers human health and causes great burden to the families and society.Studies have shown that the damage of hypertension to target organs such as heart,brain and kidney is not only related to the blood pressure level,but also related to the circadian rhythm of blood pressure.Hypertension chronotherapy adjusts the time of administration through the characteristics of blood pressure rhythm,restores blood pressure to normal circadian rhythm and provides optimal treatment for the patients with hypertension.This article reviews the circadian rhythm of blood pressure,target organ injury and chronotherapy.