星形胶质细胞缝隙连接在脑缺血再灌注损伤中的研究进展

Research Progress on the Protective Effect of Astrocytes in Cerebral Ischemia-Reperfusion Injury

缺血性脑血管病(ischemic cerebrovascular disease,ICVD)在临床疾病中属于常见的一类疾病,在脑血管疾病中占比约有70%以上。胶质细胞在神经系统中的数量是最多的,远超过神经元。星形胶质细胞的线粒体功能发生障碍,导致神经元在存活和发挥正常的生理功能方面出现问题。缝隙连接蛋白(connexin,CX)是执行这个功能的关键蛋白,CX构成了缝隙连接通道,在病理过程中发挥了重要作用。该文综述了星形胶质细胞的缝隙连接蛋白43对脑缺血发挥保护作用的研究进展。

Ischemic cerebrovascular disease(ICVD) is a common disease in clinical diseases,accounting for more than 70% of cerebrovascular diseases. The number of glial cells in the nervous system is the largest,far more than neurons. The mitochondrial function of astrocytes is impaired,resulting in problems in the survival and normal physiological function of neurons.Connexin is the key protein to perform this function. Connexin constitutes the gap junction channel and plays an important role in the pathological process.This article reviews the progress of the protective effect of gap junction protein 43 of astrocyte on cerebral ischemia.