肝脏疾病细胞铁死亡研究进展

Ferroptosis in chronic liver diseases

目的铁死亡是一种新发现的细胞死亡方式,是由于细胞内铁离子水平异常升高,导致氧化还原失衡,细胞膜发生脂质过氧化,最终细胞膜破裂,导致细胞死亡。目前认为铁死亡的中心环节是铁代谢和活性氧代谢。铁死亡可以影响多种疾病的发生发展过程,例如神经退行性疾病、肿瘤、缺血再灌注损伤、免疫性疾病等。越来越多的研究表明,在多种肝脏疾病的发生发展过程中均出现不同程度的铁超载和脂质活性氧堆积等铁死亡特征。铁死亡可以通过调节细胞内铁离子水平和脂质过氧化程度影响肝脏疾病的进程。本文将针对肝脏疾病发病过程中细胞铁死亡研究进展进行综述。

Objective Ferroptosis is a newly discovered mode of cell death,which is caused by the abnormal increase of intracellular iron ion levels,resulting in the imbalance of redox,lipid peroxidation of cell membrane,and finally cell death owing to cell membrane rupture.At present,the central link of ferroptosis is iron metabolism and reactive oxygen metabolism.Ferroptosis can affect the occurrence and development of a variety of diseases,such as neurodegenerative diseases,tumors,ischemia-reperfusion injury,immunoimbalance diseases,etc.Increasing numbers of studies have shown that the characteristics of ferroptosis,such as iron overload and accumulation of lipid reactive oxygen species,occur in the development many liver diseases.Ferroptosis can affect the progression of liver diseases by regulating the intracellular iron ion levels and lipid peroxidation degree.In this review,we put emphasis on the research progress of ferroptosis in liver diseases.